SNP Detail For rs998731
1.Mapping Information
Human SNP ID rs998731
Human chromosome chr8
Human SNP position 80183160
Pig chromosome chr4
Pig SNP position 61648963
2.Annotation Information
PubMed ID24390342
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/24390342
StudyGenetics of rheumatoid arthritis contributes to biology and drug discovery.
Disease/TraitRheumatoid arthritis
Initial sampleup to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls
Replication sampleup to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls
Region8q21.13
Chromosome idchr8
Chromosome position80183160
Reported geneTPD52
Mapped geneLOC105375920
Upstream gene id
Downstream gene id
SNP gene ids105375920
Upstream gene distance
Downstream gene distance
SNP risk allelers998731-T
SNPsrs998731
Merged0
SNP id current998731
Contextintron_variant
Intergenic0
Allele frequency0.44
P value0.000000007
Pvalue mlog8.15490195998574
P value text(EA)
Or beta1.09
%95 Ci[1.06-1.12]
PlatformAffymetrix, Illumina [up to 9739303] (imputed)
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST002318
PubMed ID24390342
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/24390342
StudyGenetics of rheumatoid arthritis contributes to biology and drug discovery.
Disease/TraitRheumatoid arthritis
Initial sampleup to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls
Replication sampleup to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls
Region8q21.13
Chromosome idchr8
Chromosome position80183160
Reported geneTPD52
Mapped geneLOC105375920
Upstream gene id
Downstream gene id
SNP gene ids105375920
Upstream gene distance
Downstream gene distance
SNP risk allelers998731-T
SNPsrs998731
Merged0
SNP id current998731
Contextintron_variant
Intergenic0
Allele frequency0.56
P value0.00000002
Pvalue mlog7.69897000433601
P value text
Or beta1.08
%95 Ci[1.05-1.11]
PlatformAffymetrix, Illumina [up to 9739303] (imputed)
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST002318