SNP Detail For rs9895661
1.Mapping Information
Human SNP ID rs9895661
Human chromosome chr17
Human SNP position 61379228
Pig chromosome chr12
Pig SNP position 38360247
2.Annotation Information
PubMed ID20383146
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20383146
StudyNew loci associated with kidney function and chronic kidney disease.
Disease/TraitChronic kidney disease
Initial sampleUp to 67,093 European ancestry individuals
Replication sampleUp to 22,982 European ancestry individuals
Region17q23.2
Chromosome idchr17
Chromosome position61379228
Reported geneBCAS3, TBX2, C17orf82
Mapped geneLOC101927855, BCAS3
Upstream gene id
Downstream gene id
SNP gene ids101927855, 54828
Upstream gene distance
Downstream gene distance
SNP risk allelers9895661-C
SNPsrs9895661
Merged0
SNP id current9895661
Contextnon_coding_transcript_exon_variant
Intergenic0
Allele frequency0.19
P value0.000000000000001
Pvalue mlog15
P value text(eGFRcrea)
Or beta0.01
%95 Ci[0.007-0.015] ml/min/1.73 m2 decrease
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitchronic kidney disease, serum creatinine measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003884, http://www.ebi.ac.uk/efo/EFO_0004518
Study accessionGCST000649
PubMed ID22797727
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22797727
StudyMeta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Disease/TraitRenal function-related traits (sCR)
Initial sample42,257 East Asian, South Asian, and South East Asian ancestry individuals
Replication sample19,662 East Asian ancestry individuals
Region17q23.2
Chromosome idchr17
Chromosome position61379228
Reported geneBCAS3
Mapped geneLOC101927855, BCAS3
Upstream gene id
Downstream gene id
SNP gene ids101927855, 54828
Upstream gene distance
Downstream gene distance
SNP risk allelers9895661-C
SNPsrs9895661
Merged0
SNP id current9895661
Contextnon_coding_transcript_exon_variant
Intergenic0
Allele frequency0.52
P value0.00000000007
Pvalue mlog10.1549019599857
P value text
Or beta0.0045
%95 Ci[0.0031-0.0059] mg/dl increase
PlatformAffymetrix, Illumina [2353587] (imputed)
CNVN
Mapped traitrenal system measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004742
Study accessionGCST001606
PubMed ID22797727
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22797727
StudyMeta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Disease/TraitRenal function-related traits (eGRFcrea)
Initial sample42,451 East Asian, South Asian, and South East Asian ancestry individuals
Replication sample19,636 East Asian ancestry individuals
Region17q23.2
Chromosome idchr17
Chromosome position61379228
Reported geneBCAS3
Mapped geneLOC101927855, BCAS3
Upstream gene id
Downstream gene id
SNP gene ids101927855, 54828
Upstream gene distance
Downstream gene distance
SNP risk allelers9895661-C
SNPsrs9895661
Merged0
SNP id current9895661
Contextnon_coding_transcript_exon_variant
Intergenic0
Allele frequency0.52
P value0.00000000005
Pvalue mlog10.3010299956639
P value text
Or beta0.0051
%95 Ci[0.0035-0.0067] ml/min/1.73m2 decrease
PlatformAffymetrix, Illumina [2353587] (imputed)
CNVN
Mapped traitrenal system measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004742
Study accessionGCST001607