SNP Detail For rs987237
1.Mapping Information
Human SNP ID rs987237
Human chromosome chr6
Human SNP position 50835337
Pig chromosome JH118430-1
Pig SNP position 228091
2.Annotation Information
PubMed ID19557161
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19557161
StudyGenome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
Disease/TraitAdiposity
Initial sample38,580 European ancestry individuals
Replication sampleUp to 102,064 European ancestry individuals
Region6p12.3
Chromosome idchr6
Chromosome position50835337
Reported geneTFAP2B
Mapped geneTFAP2B
Upstream gene id
Downstream gene id
SNP gene ids7021
Upstream gene distance
Downstream gene distance
SNP risk allelers987237-G
SNPsrs987237
Merged0
SNP id current987237
Contextintron_variant
Intergenic0
Allele frequency0.164
P value0.00000000002
Pvalue mlog10.698970004336
P value text(WC)
Or beta0.04
%95 Ci[0.03-0.05] z-score unit increase
PlatformAffymetrix, Illumina [2573738] (imputed)
CNVN
Mapped traitobesity
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001073
Study accessionGCST000428
PubMed ID20935630
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20935630
StudyAssociation analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Disease/TraitBody mass index
Initial sampleUp to 123,865 European ancestry individuals
Replication sampleUp to 125,931 European ancestry individuals
Region6p12.3
Chromosome idchr6
Chromosome position50835337
Reported geneTFAP2B
Mapped geneTFAP2B
Upstream gene id
Downstream gene id
SNP gene ids7021
Upstream gene distance
Downstream gene distance
SNP risk allelers987237-G
SNPsrs987237
Merged0
SNP id current987237
Contextintron_variant
Intergenic0
Allele frequency0.18
P value3E-20
Pvalue mlog19.5228787452803
P value text
Or beta0.13
%95 Ci[0.07-0.19] kg/m2 increase
PlatformAffymetrix, Illumina, Perlegen [~ 2800000] (imputed)
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST000830
PubMed ID23563607
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23563607
StudyGenome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Disease/TraitBody mass index
Initial sample7,962 European ancestry high body mass index individuals, 8,106 European ancestry low body mass index individuals
Replication sample4,900 European ancestry high body mass index individuals, 4,891 European ancestry low body mass index individuals
Region6p12.3
Chromosome idchr6
Chromosome position50835337
Reported geneTFAP2B
Mapped geneTFAP2B
Upstream gene id
Downstream gene id
SNP gene ids7021
Upstream gene distance
Downstream gene distance
SNP risk allelers987237-G
SNPsrs987237
Merged0
SNP id current987237
Contextintron_variant
Intergenic0
Allele frequency0.18
P value0.00000000002
Pvalue mlog10.698970004336
P value text
Or beta1.2
%95 Ci[NR]
PlatformAffymetrix, Illumina [~ 2800000] (imputed)
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST001955
PubMed ID26604143
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26604143
StudyGenome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
Disease/TraitChildhood body mass index
Initial sample34,744 European ancestry children
Replication sample11,313 European ancestry children
Region6p12.3
Chromosome idchr6
Chromosome position50835337
Reported geneTFAP2B
Mapped geneTFAP2B
Upstream gene id
Downstream gene id
SNP gene ids7021
Upstream gene distance
Downstream gene distance
SNP risk allelers987237-G
SNPsrs987237
Merged0
SNP id current987237
Contextintron_variant
Intergenic0
Allele frequency0.19
P value0.000000000002
Pvalue mlog11.698970004336
P value text
Or beta0.062
%95 Ci[0.044-0.08] unit increase
PlatformAffymetrix, Illumina [2499691] (imputed)
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST003177