SNP Detail For rs9543325
1.Mapping Information
Human SNP ID rs9543325
Human chromosome chr13
Human SNP position 73342491
Pig chromosome chr11
Pig SNP position 50181377
2.Annotation Information
PubMed ID20101243
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20101243
StudyA genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
Disease/TraitPancreatic cancer
Initial sample3,851 European, Chinese and other ancestry cases, 3,934 European, Chinese and other ancestry controls
Replication sampleNA
Region13q22.1
Chromosome idchr13
Chromosome position73342491
Reported geneKLF12, KLF5
Mapped geneRNU6-66P - LINC00393
Upstream gene id100873770
Downstream gene id100874156
SNP gene ids
Upstream gene distance229473
Downstream gene distance114408
SNP risk allelers9543325-C
SNPsrs9543325
Merged0
SNP id current9543325
Contextintergenic_variant
Intergenic1
Allele frequency0.37
P value0.00000000003
Pvalue mlog10.5228787452803
P value text
Or beta1.26
%95 Ci[1.18-1.35]
PlatformIllumina [551766]
CNVN
Mapped traitpancreatic carcinoma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0002618
Study accessionGCST000574
PubMed ID25086665
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25086665
StudyGenome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
Disease/TraitPancreatic cancer
Initial sample1,582 European ancestry cases, 5,203 European ancestry controls
Replication sample6,101 European ancestry cases, 9,194 European ancestry controls
Region13q22.1
Chromosome idchr13
Chromosome position73342491
Reported geneKLF12, KLF5
Mapped geneRNU6-66P - LINC00393
Upstream gene id100873770
Downstream gene id100874156
SNP gene ids
Upstream gene distance229473
Downstream gene distance114408
SNP risk allelers9543325-?
SNPsrs9543325
Merged0
SNP id current9543325
Contextintergenic_variant
Intergenic1
Allele frequencyNR
P value0.00000000000004
Pvalue mlog13.397940008672
P value text
Or beta1.23
%95 Ci[1.18-1.30]
PlatformIllumina [608202]
CNVN
Mapped traitpancreatic carcinoma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0002618
Study accessionGCST002553
PubMed ID26098869
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26098869
StudyCommon variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
Disease/TraitPancreatic cancer
Initial sample7,638 cases, 7,364 controls
Replication sample2,287 cases, 4,205 controls
Region13q22.1
Chromosome idchr13
Chromosome position73342491
Reported geneKLF5, KLF12
Mapped geneRNU6-66P - LINC00393
Upstream gene id100873770
Downstream gene id100874156
SNP gene ids
Upstream gene distance229473
Downstream gene distance114408
SNP risk allelers9543325-?
SNPsrs9543325
Merged0
SNP id current9543325
Contextintergenic_variant
Intergenic1
Allele frequencyNR
P value0.0000000002
Pvalue mlog9.69897000433601
P value text
Or beta1.24
%95 Ci[1.16-1.32]
PlatformIllumina [866891] (imputed)
CNVN
Mapped traitpancreatic carcinoma
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0002618
Study accessionGCST002991