Human SNP ID | rs9272346 |
---|---|
Human chromosome | chr6 |
Human SNP position | 32636595 |
Pig chromosome | chr7 |
Pig SNP position | 29164498 |
PubMed ID | 17554300 |
---|---|
Journal | Nature |
Link | www.ncbi.nlm.nih.gov/pubmed/17554300 |
Study | Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. |
Disease/Trait | Type 1 diabetes |
Initial sample | 1,963 European ancestry cases, 2,938 European ancestry controls |
Replication sample | (see Todd 2007) |
Region | 6p21.32 |
Chromosome id | chr6 |
Chromosome position | 32636595 |
Reported gene | MHC |
Mapped gene | HLA-DRB1 - HLA-DQA1 |
Upstream gene id | 3123 |
Downstream gene id | 3117 |
SNP gene ids | |
Upstream gene distance | 46759 |
Downstream gene distance | 801 |
SNP risk allele | rs9272346-G |
SNPs | rs9272346 |
Merged | 0 |
SNP id current | 9272346 |
Context | intron_variant |
Intergenic | 1 |
Allele frequency | 0.61 |
P value | 5E-134 |
Pvalue mlog | 133.301029995663 |
P value text | |
Or beta | 5.49 |
%95 Ci | [4.83-6.24] |
Platform | Affymetrix [469557] |
CNV | N |
Mapped trait | type I diabetes mellitus |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001359 |
Study accession | GCST000043 |
PubMed ID | 18978792 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/18978792 |
Study | Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. |
Disease/Trait | Type 1 diabetes |
Initial sample | 3,561 European ancestry cases, 4,646 European ancestry controls |
Replication sample | 6,225 European ancestry cases, 6,946 European ancestry controls, 3,064 European ancestry trios from 2,828 families |
Region | 6p21.32 |
Chromosome id | chr6 |
Chromosome position | 32636595 |
Reported gene | HLA |
Mapped gene | HLA-DRB1 - HLA-DQA1 |
Upstream gene id | 3123 |
Downstream gene id | 3117 |
SNP gene ids | |
Upstream gene distance | 46759 |
Downstream gene distance | 801 |
SNP risk allele | rs9272346-G |
SNPs | rs9272346 |
Merged | 0 |
SNP id current | 9272346 |
Context | intron_variant |
Intergenic | 1 |
Allele frequency | NR |
P value | 6E-129 |
Pvalue mlog | 128.221848749616 |
P value text | |
Or beta | |
%95 Ci | |
Platform | Affymetrix [up to 335565] |
CNV | N |
Mapped trait | type I diabetes mellitus |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001359 |
Study accession | GCST000258 |
PubMed ID | 23181788 |
Journal | Clin Exp Allergy |
Link | www.ncbi.nlm.nih.gov/pubmed/23181788 |
Study | HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults. |
Disease/Trait | Asthma |
Initial sample | Up to 1,238 European ancestry cases, up to 2,617 European ancestry controls |
Replication sample | Up to 1,837 European ancestry cases, up to 3,803 European ancestry controls, up to 2,806 cases, up to 2,150 controls, up to 603 Costa Rican ancestry cases and their parents |
Region | 6p21.32 |
Chromosome id | chr6 |
Chromosome position | 32636595 |
Reported gene | HLA-DQA1 |
Mapped gene | HLA-DRB1 - HLA-DQA1 |
Upstream gene id | 3123 |
Downstream gene id | 3117 |
SNP gene ids | |
Upstream gene distance | 46759 |
Downstream gene distance | 801 |
SNP risk allele | rs9272346-? |
SNPs | rs9272346 |
Merged | 0 |
SNP id current | 9272346 |
Context | intron_variant |
Intergenic | 1 |
Allele frequency | NR |
P value | 0.00000002 |
Pvalue mlog | 7.69897000433601 |
P value text | (Adult) |
Or beta | |
%95 Ci | |
Platform | Affymetrix [455089] |
CNV | N |
Mapped trait | asthma |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000270 |
Study accession | GCST001763 |