Human SNP ID | rs9262631 |
---|---|
Human chromosome | chr6 |
Human SNP position | 31056824 |
Pig chromosome | chr7 |
Pig SNP position | 27349773 |
PubMed ID | 26151496 |
---|---|
Journal | Nat Commun |
Link | www.ncbi.nlm.nih.gov/pubmed/26151496 |
Study | Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study. |
Disease/Trait | Thionamide-induced agranulocytosis in Graves__ disease |
Initial sample | 21 East Asian ancestry cases with agranulocytosis, 662 East Asian ancestry cases without agranulocytosis |
Replication sample | 21 East Asian ancestry cases with agranulocytosis, 546 East Asian ancestry cases without agranulocytosis |
Region | 6p21.33 |
Chromosome id | chr6 |
Chromosome position | 31056824 |
Reported gene | HLA |
Mapped gene | HCG22 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 285834 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs9262631-A |
SNPs | rs9262631 |
Merged | |
SNP id current | 9262631 |
Context | non_coding_transcript_exon_variant |
Intergenic | 0 |
Allele frequency | 0.063 |
P value | 6E-19 |
Pvalue mlog | 18.2218487496163 |
P value text | (trend) |
Or beta | 7.09 |
%95 Ci | [4.32-11.63] (allelic) |
Platform | Affymetrix [522980] |
CNV | N |
Mapped trait | drug-induced agranulocytosis, response to thioamide, Graves disease |
Mapped trait URI | http://purl.obolibrary.org/obo/HP_0012235, http://www.ebi.ac.uk/efo/EFO_0007633, http://www.ebi.ac.uk/efo/EFO_0004237 |
Study accession | GCST003018 |