SNP Detail For rs925489
1.Mapping Information
Human SNP ID rs925489
Human chromosome chr9
Human SNP position 97784318
Pig chromosome chr1
Pig SNP position 267770738
2.Annotation Information
PubMed ID22493691
JournalPLoS One
Linkwww.ncbi.nlm.nih.gov/pubmed/22493691
StudyNovel associations for hypothyroidism include known autoimmune risk loci.
Disease/TraitHypothyroidism
Initial sample3,736 European ancestry cases, 35,546 European ancestry controls
Replication sampleNA
Region9q22.33
Chromosome idchr9
Chromosome position97784318
Reported geneKRT18P13, FOXE1, C9orf156
Mapped genePTCSC2
Upstream gene id
Downstream gene id
SNP gene ids101928337
Upstream gene distance
Downstream gene distance
SNP risk allelers925489-T
SNPsrs925489
Merged0
SNP id current925489
Contextintergenic_variant
Intergenic0
Allele frequency0.668
P value2E-19
Pvalue mlog18.698970004336
P value text
Or beta1.28
%95 Ci[1.22-1.35]
PlatformIllumina [870065]
CNVN
Mapped traithypothyroidism
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004705
Study accessionGCST001474
PubMed ID24852370
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24852370
StudyGenome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.
Disease/TraitSerum thyroid-stimulating hormone levels
Initial sample1,346 Han Chinese ancestry individuals
Replication sample3,235 She Chinese ancestry individuals
Region9q22.33
Chromosome idchr9
Chromosome position97784318
Reported geneXPA, FOXE1
Mapped genePTCSC2
Upstream gene id
Downstream gene id
SNP gene ids101928337
Upstream gene distance
Downstream gene distance
SNP risk allelers925489-C
SNPsrs925489
Merged0
SNP id current925489
Contextintergenic_variant
Intergenic0
Allele frequency0.109
P value0.0000000000001
Pvalue mlog13
P value text
Or beta0.058
%95 Ci[NR] unit decrease
PlatformIllumina [8503852] (imputed)
CNVN
Mapped traitthyroid stimulating hormone measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004748
Study accessionGCST002458