SNP Detail For rs921720
1.Mapping Information
Human SNP ID rs921720
Human chromosome chr8
Human SNP position 125522429
Pig chromosome chr4
Pig SNP position 14840421
2.Annotation Information
PubMed ID23251661
JournalPLoS One
Linkwww.ncbi.nlm.nih.gov/pubmed/23251661
StudyNovel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Disease/TraitObesity-related traits
Initial sample815 Hispanic children from 263 families
Replication sampleNA
Region8q24.13
Chromosome idchr8
Chromosome position125522429
Reported geneTRIB1
Mapped geneLOC105375745
Upstream gene id
Downstream gene id
SNP gene ids105375745
Upstream gene distance
Downstream gene distance
SNP risk allelers921720-A
SNPsrs921720
Merged0
SNP id current921720
Contextintron_variant
Intergenic0
Allele frequency0.414
P value0.000003
Pvalue mlog5.52287874528033
P value text(Gestational age )
Or beta0.05
%95 Ci[NR] wk increase
PlatformIllumina [899892]
CNVN
Mapped traitgestational age
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005112
Study accessionGCST001762
PubMed ID23128233
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/23128233
StudyHost-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Disease/TraitInflammatory bowel disease
Initial sample12,924 European ancestry cases, 21,442 European ancestry controls
Replication sample25,683 European ancestry cases, 17,015 European ancestry controls
Region8q24.13
Chromosome idchr8
Chromosome position125522429
Reported geneTRIB1
Mapped geneLOC105375745
Upstream gene id
Downstream gene id
SNP gene ids105375745
Upstream gene distance
Downstream gene distance
SNP risk allelers921720-G
SNPsrs921720
Merged0
SNP id current921720
Contextintron_variant
Intergenic0
Allele frequency0.609
P value8E-20
Pvalue mlog19.096910013008
P value text
Or beta1.081
%95 Ci[1.049-1.113]
PlatformAffymetrix, Illumina [1230000] (imputed)
CNVN
Mapped traitinflammatory bowel disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003767
Study accessionGCST001725
PubMed ID26192919
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26192919
StudyAssociation analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Disease/TraitCrohn__s disease
Initial sample5,956 European ancestry cases, 14,927 European ancestry controls
Replication sample14,594 European ancestry cases, 26,715 European ancestry controls, 151 Iranian ancestry cases, 342 Iranian ancestry controls, 184 Indian ancestry cases, 990 Indian ancestry controls, 1,690 East Asian ancestry cases, 3,719 East Asian ancestry controls
Region8q24.13
Chromosome idchr8
Chromosome position125522429
Reported geneNR
Mapped geneLOC105375745
Upstream gene id
Downstream gene id
SNP gene ids105375745
Upstream gene distance
Downstream gene distance
SNP risk allelers921720-A
SNPsrs921720
Merged0
SNP id current921720
Contextintron_variant
Intergenic0
Allele frequency0.62
P value1E-21
Pvalue mlog21
P value text(EA)
Or beta1.1255294
%95 Ci
PlatformAffymetrix, Illumina [~ 9000000] (imputed)
CNVN
Mapped traitCrohn__s disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000384
Study accessionGCST003044