Human SNP ID | rs909674 |
---|---|
Human chromosome | chr22 |
Human SNP position | 39463164 |
Pig chromosome | chr5 |
Pig SNP position | 6097633 |
PubMed ID | 23382691 |
---|---|
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 1,848 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.29096 |
P value | 0.00000003 |
Pvalue mlog | 7.52287874528033 |
P value text | (IgG1G0N) |
Or beta | 0.083 |
%95 Ci | [0.054-0.112] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001849 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 1,848 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.29096 |
P value | 0.0000000002 |
Pvalue mlog | 9.69897000433601 |
P value text | (IgG1G1N) |
Or beta | 0.0721 |
%95 Ci | [0.050-0.094] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001849 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 1,848 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.29096 |
P value | 0.000009 |
Pvalue mlog | 5.04575749056067 |
P value text | (IgG1G2N) |
Or beta | 0.0651 |
%95 Ci | [0.036-0.094] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001849 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.298923567230632 |
P value | 0.0000000005 |
Pvalue mlog | 9.30102999566398 |
P value text | (IGP22) |
Or beta | 0.2099 |
%95 Ci | [0.14-0.28] unit decrease |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.299100489968792 |
P value | 0.000002 |
Pvalue mlog | 5.69897000433601 |
P value text | (IGP30) |
Or beta | 0.1606 |
%95 Ci | [0.095-0.227] unit decrease |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.298878222915738 |
P value | 0.0000000002 |
Pvalue mlog | 9.69897000433601 |
P value text | (IGP34) |
Or beta | 0.2136 |
%95 Ci | [0.15-0.28] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.298476014725569 |
P value | 9E-24 |
Pvalue mlog | 23.0457574905606 |
P value text | (IGP39) |
Or beta | 0.3388 |
%95 Ci | [0.27-0.4] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.299013119715176 |
P value | 1E-24 |
Pvalue mlog | 24 |
P value text | (IGP40) |
Or beta | 0.3447 |
%95 Ci | [0.28-0.41] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.299013119715176 |
P value | 0.0000000000003 |
Pvalue mlog | 12.5228787452803 |
P value text | (IGP45) |
Or beta | 0.2468 |
%95 Ci | [0.18-0.31] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.299056983073497 |
P value | 0.000000003 |
Pvalue mlog | 8.52287874528033 |
P value text | (IGP49) |
Or beta | 0.2003 |
%95 Ci | [0.13-0.27] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.298923567230632 |
P value | 0.0000000001 |
Pvalue mlog | 10 |
P value text | (IGP5) |
Or beta | 0.2178 |
%95 Ci | [0.15-0.28] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.299146468388246 |
P value | 0.0000000002 |
Pvalue mlog | 9.69897000433601 |
P value text | (IGP62) |
Or beta | 0.2148 |
%95 Ci | [0.15-0.28] unit decrease |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.299013119715176 |
P value | 0.00000003 |
Pvalue mlog | 7.52287874528033 |
P value text | (IGP64) |
Or beta | 0.1872 |
%95 Ci | [0.12-0.25] unit decrease |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.299013119715176 |
P value | 0.0000000000000001 |
Pvalue mlog | 16 |
P value text | (IGP66) |
Or beta | 0.281 |
%95 Ci | [0.21-0.35] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.298923976402493 |
P value | 0.0000000006 |
Pvalue mlog | 9.22184874961635 |
P value text | (IGP68) |
Or beta | 0.2094 |
%95 Ci | [0.14-0.28] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.299323467231387 |
P value | 0.000009 |
Pvalue mlog | 5.04575749056067 |
P value text | (IGP69) |
Or beta | 0.151 |
%95 Ci | [0.084-0.218] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | NR |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.299013119715176 |
P value | 0.0000000000000004 |
Pvalue mlog | 15.397940008672 |
P value text | (IGP70) |
Or beta | 0.2754 |
%95 Ci | [0.21-0.34] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.299013119715176 |
P value | 0.0000000000000006 |
Pvalue mlog | 15.2218487496163 |
P value text | (IGP71) |
Or beta | 0.2737 |
%95 Ci | [0.21-0.34] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.299146275601069 |
P value | 0.000000000000002 |
Pvalue mlog | 14.698970004336 |
P value text | (IGP72) |
Or beta | 0.2695 |
%95 Ci | [0.2-0.34] unit decrease |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3, TAB1, CACNA1I, SYNGR1 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.299056983073497 |
P value | 0.000000003 |
Pvalue mlog | 8.52287874528033 |
P value text | (IGP9) |
Or beta | 0.2011 |
%95 Ci | [0.13-0.27] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 26634245 |
Journal | BMC Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/26634245 |
Study | A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. |
Disease/Trait | Post bronchodilator FEV1 |
Initial sample | 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals |
Replication sample | NA |
Region | 22q13.1 |
Chromosome id | chr22 |
Chromosome position | 39463164 |
Reported gene | MGAT3 |
Mapped gene | MGAT3 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 4248 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs909674-C |
SNPs | rs909674 |
Merged | 0 |
SNP id current | 909674 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.926 |
P value | 0.000002 |
Pvalue mlog | 5.69897000433601 |
P value text | (AA) |
Or beta | 0.143 |
%95 Ci | NR unit increase |
Platform | Illumina [NR] (imputed) |
CNV | N |
Mapped trait | forced expiratory volume, response to bronchodilator |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004314, http://purl.obolibrary.org/obo/GO_0097366 |
Study accession | GCST003262 |