SNP Detail For rs887912
1.Mapping Information
Human SNP ID rs887912
Human chromosome chr2
Human SNP position 59075742
Pig chromosome chr3
Pig SNP position 87000147
2.Annotation Information
PubMed ID20935630
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20935630
StudyAssociation analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Disease/TraitBody mass index
Initial sampleUp to 123,865 European ancestry individuals
Replication sampleUp to 125,931 European ancestry individuals
Region2p16.1
Chromosome idchr2
Chromosome position59075742
Reported geneFANCL
Mapped geneLINC01122 - LOC101927285
Upstream gene id400955
Downstream gene id101927285
SNP gene ids
Upstream gene distance11976
Downstream gene distance141966
SNP risk allelers887912-T
SNPsrs887912
Merged0
SNP id current887912
Contextintergenic_variant
Intergenic1
Allele frequency0.29
P value0.000000000002
Pvalue mlog11.698970004336
P value text
Or beta0.1
%95 Ci[0.06-0.14] kg/m2 increase
PlatformAffymetrix, Illumina, Perlegen [~ 2800000] (imputed)
CNVN
Mapped traitbody mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST000830
PubMed ID23563607
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23563607
StudyGenome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Disease/TraitObesity
Initial sample93,015 European ancestry overweight individuals, 32,858 European ancestry class I obese individuals, 9,889 European ancestry class II obese individuals, 2,896 European ancestry class III obese individuals, up to 65,840 European ancestry controls
Replication sample65,332 European ancestry overweight individuals, 22,373 European ancestry class I obese individuals, 5,476 European ancestry class II obese individuals, 1,162 European ancestry class III obese individuals, up to 39,294 European ancestry controls
Region2p16.1
Chromosome idchr2
Chromosome position59075742
Reported geneFANCL
Mapped geneLINC01122 - LOC101927285
Upstream gene id400955
Downstream gene id101927285
SNP gene ids
Upstream gene distance11976
Downstream gene distance141966
SNP risk allelers887912-T
SNPsrs887912
Merged0
SNP id current887912
Contextintergenic_variant
Intergenic1
Allele frequency0.28
P value0.0000000001
Pvalue mlog10
P value text(Obesity class I)
Or beta1.07
%95 Ci[NR]
PlatformAffymetrix, Illumina [~ 2800000] (imputed)
CNVN
Mapped traitobesity
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001073
Study accessionGCST001953
PubMed ID23563607
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23563607
StudyGenome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Disease/TraitObesity
Initial sample93,015 European ancestry overweight individuals, 32,858 European ancestry class I obese individuals, 9,889 European ancestry class II obese individuals, 2,896 European ancestry class III obese individuals, up to 65,840 European ancestry controls
Replication sample65,332 European ancestry overweight individuals, 22,373 European ancestry class I obese individuals, 5,476 European ancestry class II obese individuals, 1,162 European ancestry class III obese individuals, up to 39,294 European ancestry controls
Region2p16.1
Chromosome idchr2
Chromosome position59075742
Reported geneFANCL
Mapped geneLINC01122 - LOC101927285
Upstream gene id400955
Downstream gene id101927285
SNP gene ids
Upstream gene distance11976
Downstream gene distance141966
SNP risk allelers887912-T
SNPsrs887912
Merged0
SNP id current887912
Contextintergenic_variant
Intergenic1
Allele frequency0.28
P value0.000000006
Pvalue mlog8.22184874961635
P value text(Obesity class II)
Or beta1.1
%95 Ci[NR]
PlatformAffymetrix, Illumina [~ 2800000] (imputed)
CNVN
Mapped traitobesity
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001073
Study accessionGCST001953