SNP Detail For rs880315
1.Mapping Information
Human SNP ID rs880315
Human chromosome chr1
Human SNP position 10736809
Pig chromosome chr6
Pig SNP position 64897724
2.Annotation Information
PubMed ID21572416
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21572416
StudyMeta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
Disease/TraitBlood pressure
Initial sample19,608 East Asian ancestry individuals
Replication sample30,765 East Asian ancestry individuals
Region1p36.22
Chromosome idchr1
Chromosome position10736809
Reported geneCASZ1
Mapped geneCASZ1
Upstream gene id
Downstream gene id
SNP gene ids54897
Upstream gene distance
Downstream gene distance
SNP risk allelers880315-C
SNPsrs880315
Merged0
SNP id current880315
Contextintron_variant
Intergenic0
Allele frequency0.65
P value0.0000007
Pvalue mlog6.15490195998574
P value text(Systolic)
Or beta0.74
%95 Ci[0.45-1.03] mm Hg increase
PlatformAffymetrix, Illumina [1700000] (imputed)
CNVN
Mapped traitsystolic blood pressure
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006335
Study accessionGCST001072
PubMed ID21572416
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21572416
StudyMeta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
Disease/TraitBlood pressure
Initial sample19,608 East Asian ancestry individuals
Replication sample30,765 East Asian ancestry individuals
Region1p36.22
Chromosome idchr1
Chromosome position10736809
Reported geneCASZ1
Mapped geneCASZ1
Upstream gene id
Downstream gene id
SNP gene ids54897
Upstream gene distance
Downstream gene distance
SNP risk allelers880315-C
SNPsrs880315
Merged0
SNP id current880315
Contextintron_variant
Intergenic0
Allele frequency0.65
P value0.0000000003
Pvalue mlog9.52287874528033
P value text(Diastolic)
Or beta0.56
%95 Ci[0.38-0.74] mm Hg increase
PlatformAffymetrix, Illumina [1700000] (imputed)
CNVN
Mapped traitdiastolic blood pressure
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006336
Study accessionGCST001074
PubMed ID25249183
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25249183
StudyGenome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
Disease/TraitSystolic blood pressure
Initial sample11,816 Han Chinese ancestry individuals
Replication sample69,146 Han Chinese ancestry individuals
Region1p36.22
Chromosome idchr1
Chromosome position10736809
Reported geneCASZ1
Mapped geneCASZ1
Upstream gene id
Downstream gene id
SNP gene ids54897
Upstream gene distance
Downstream gene distance
SNP risk allelers880315-C
SNPsrs880315
Merged0
SNP id current880315
Contextintron_variant
Intergenic0
Allele frequency0.63
P value0.0000000006
Pvalue mlog9.22184874961635
P value text
Or beta0.97
%95 Ci[0.66-1.28] unit increase
PlatformAffymetrix, Illumina [2485448] (imputed)
CNVN
Mapped traitsystolic blood pressure
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006335
Study accessionGCST002630
PubMed ID25249183
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25249183
StudyGenome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
Disease/TraitDiastolic blood pressure
Initial sample11,816 Han Chinese ancestry individuals
Replication sample69,146 Han Chinese ancestry individuals
Region1p36.22
Chromosome idchr1
Chromosome position10736809
Reported geneCASZ1
Mapped geneCASZ1
Upstream gene id
Downstream gene id
SNP gene ids54897
Upstream gene distance
Downstream gene distance
SNP risk allelers880315-C
SNPsrs880315
Merged0
SNP id current880315
Contextintron_variant
Intergenic0
Allele frequency0.63
P value0.00000008
Pvalue mlog7.09691001300805
P value text
Or beta0.46
%95 Ci[0.28-0.64] unit increase
PlatformAffymetrix, Illumina [2485448] (imputed)
CNVN
Mapped traitdiastolic blood pressure
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0006336
Study accessionGCST002631
PubMed ID25249183
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25249183
StudyGenome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
Disease/TraitHypertension
Initial sample5,065 Han Chinese ancestry cases, 4,404 Han Chinese ancestry controls
Replication sample29,799 Han Chinese ancestry cases, 39,347 Han Chinese ancestry controls
Region1p36.22
Chromosome idchr1
Chromosome position10736809
Reported geneCASZ1
Mapped geneCASZ1
Upstream gene id
Downstream gene id
SNP gene ids54897
Upstream gene distance
Downstream gene distance
SNP risk allelers880315-C
SNPsrs880315
Merged0
SNP id current880315
Contextintron_variant
Intergenic0
Allele frequency0.63
P value0.000000002
Pvalue mlog8.69897000433601
P value text
Or beta
%95 Ci
PlatformAffymetrix, Illumina [2485448] (imputed)
CNVN
Mapped traithypertension
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000537
Study accessionGCST002627
PubMed ID26631737
JournalDiabetes
Linkwww.ncbi.nlm.nih.gov/pubmed/26631737
StudyGenome-wide Association Studies Identify Genetic Loci Associated with Albuminuria in Diabetes.
Disease/TraitUrinary albumin-to-creatinine ratio
Initial sampleup to 54,450 European ancestry individuals
Replication sampleNA
Region1p36.22
Chromosome idchr1
Chromosome position10736809
Reported geneCASZ1
Mapped geneCASZ1
Upstream gene id
Downstream gene id
SNP gene ids54897
Upstream gene distance
Downstream gene distance
SNP risk allelers880315-T
SNPsrs880315
Merged0
SNP id current880315
Contextintron_variant
Intergenic0
Allele frequency0.65
P value0.000009
Pvalue mlog5.04575749056067
P value text
Or beta0.042
%95 Ci[0.024-0.06] unit decrease
PlatformAffymetrix, Illumina [2191945] (imputed)
CNVN
Mapped trait
Mapped trait URI
Study accessionGCST003255