SNP Detail For rs8078723
1.Mapping Information
Human SNP ID rs8078723
Human chromosome chr17
Human SNP position 40010626
Pig chromosome chr12
Pig SNP position 22797139
2.Annotation Information
PubMed ID22788528
JournalInt J Immunogenet
Linkwww.ncbi.nlm.nih.gov/pubmed/22788528
StudyGenetic associations with C-reactive protein level and white blood cell count in the KARE study.
Disease/TraitC-reactive protein and white blood cell count
Initial sample8,722 individuals
Replication sampleNA
Region17q21.1
Chromosome idchr17
Chromosome position40010626
Reported geneintergenic
Mapped genePSMD3 - CSF3
Upstream gene id5709
Downstream gene id1440
SNP gene ids
Upstream gene distance12666
Downstream gene distance4735
SNP risk allelers8078723-C
SNPsrs8078723
Merged0
SNP id current8078723
Contextupstream_gene_variant
Intergenic1
Allele frequency0.468
P value0.000000003
Pvalue mlog8.52287874528033
P value text(WBC)
Or beta0.163
%95 Ci[NR] 10^3/ul increase
PlatformAffymetrix [1701735] (imputed)
CNVN
Mapped traitleukocyte count
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004308
Study accessionGCST001605
PubMed ID21738480
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21738480
StudyMultiple loci are associated with white blood cell phenotypes.
Disease/TraitWhite blood cell count
Initial sample19,509 European ancestry individuals
Replication sample11,823 European ancestry individuals
Region17q21.1
Chromosome idchr17
Chromosome position40010626
Reported geneCSF3, GSDMB, PSMD3, MED24, GSDMA, SNORD124, THRA, NR1D1, ORMDL3
Mapped genePSMD3 - CSF3
Upstream gene id5709
Downstream gene id1440
SNP gene ids
Upstream gene distance12666
Downstream gene distance4735
SNP risk allelers8078723-T
SNPsrs8078723
Merged0
SNP id current8078723
Contextupstream_gene_variant
Intergenic1
Allele frequency
P value2E-31
Pvalue mlog30.698970004336
P value text(Neutrophils)
Or beta0.0407
%95 Ci[0.034-0.048] unit decrease
PlatformAffymetrix, Illumina [> 2400000] (imputed)
CNVN
Mapped traitneutrophil count
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004833
Study accessionGCST001137
PubMed ID25096241
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25096241
StudyTrans-ethnic meta-analysis of white blood cell phenotypes.
Disease/TraitNeutrophil count
Initial sample9,802 Japanese ancestry individuals, 16,550 European ancestry individuals, 7,391 African American individuals
Replication sampleNA
Region17q21.1
Chromosome idchr17
Chromosome position40010626
Reported geneMED24, CSF3
Mapped genePSMD3 - CSF3
Upstream gene id5709
Downstream gene id1440
SNP gene ids
Upstream gene distance12666
Downstream gene distance4735
SNP risk allelers8078723-C
SNPsrs8078723
Merged0
SNP id current8078723
Contextupstream_gene_variant
Intergenic1
Allele frequency0.626
P value3E-23
Pvalue mlog22.5228787452803
P value text(EA)
Or beta0.043
%95 Ci[0.035-0.051] unit increase
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitneutrophil count
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004833
Study accessionGCST002557
PubMed ID25096241
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25096241
StudyTrans-ethnic meta-analysis of white blood cell phenotypes.
Disease/TraitNeutrophil count
Initial sample9,802 Japanese ancestry individuals, 16,550 European ancestry individuals, 7,391 African American individuals
Replication sampleNA
Region17q21.1
Chromosome idchr17
Chromosome position40010626
Reported geneCSF3, MED24
Mapped genePSMD3 - CSF3
Upstream gene id5709
Downstream gene id1440
SNP gene ids
Upstream gene distance12666
Downstream gene distance4735
SNP risk allelers8078723-C
SNPsrs8078723
Merged0
SNP id current8078723
Contextupstream_gene_variant
Intergenic1
Allele frequency0.519
P value0.0000000001
Pvalue mlog10
P value text(Japanese)
Or beta0.032
%95 Ci[0.022-0.042] unit increase
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitneutrophil count
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004833
Study accessionGCST002557