SNP Detail For rs8005161
1.Mapping Information
Human SNP ID rs8005161
Human chromosome chr14
Human SNP position 88006251
Pig chromosome chr7
Pig SNP position 116434299
2.Annotation Information
PubMed ID21102463
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21102463
StudyGenome-wide meta-analysis increases to 71 the number of confirmed Crohn__s disease susceptibility loci.
Disease/TraitCrohn__s disease
Initial sample6,333 European ancestry cases, 15,056 European ancestry controls
Replication sample15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry trios
Region14q31.3
Chromosome idchr14
Chromosome position88006251
Reported geneGALC, GPR65
Mapped geneGPR65
Upstream gene id
Downstream gene id
SNP gene ids8477
Upstream gene distance
Downstream gene distance
SNP risk allelers8005161-T
SNPsrs8005161
Merged0
SNP id current8005161
Contextintron_variant
Intergenic0
Allele frequency0.119
P value0.000000000000000004
Pvalue mlog17.397940008672
P value text
Or beta1.23
%95 Ci[1.16-1.31]
PlatformAffymetrix, Illumina [953241] (imputed)
CNVN
Mapped traitCrohn__s disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000384
Study accessionGCST000879
PubMed ID23128233
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/23128233
StudyHost-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Disease/TraitInflammatory bowel disease
Initial sample12,924 European ancestry cases, 21,442 European ancestry controls
Replication sample25,683 European ancestry cases, 17,015 European ancestry controls
Region14q31.3
Chromosome idchr14
Chromosome position88006251
Reported geneGALC, GPR65
Mapped geneGPR65
Upstream gene id
Downstream gene id
SNP gene ids8477
Upstream gene distance
Downstream gene distance
SNP risk allelers8005161-T
SNPsrs8005161
Merged0
SNP id current8005161
Contextintron_variant
Intergenic0
Allele frequency0.089
P value0.00000000000002
Pvalue mlog13.698970004336
P value text
Or beta1.153
%95 Ci[1.097-1.211]
PlatformAffymetrix, Illumina [1230000] (imputed)
CNVN
Mapped traitinflammatory bowel disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003767
Study accessionGCST001725
PubMed ID26192919
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26192919
StudyAssociation analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Disease/TraitUlcerative colitis
Initial sample6,968 European ancestry cases, 20,464 European ancestry controls
Replication sample10,679 European ancestry cases, 26,715 European ancestry controls, 397 Iranian ancestry cases, 342 Iranian ancestry controls, 1,239 Indian ancestry cases, 990 Indian ancestry controls, 1,134 East Asian ancestry cases, 3,719 East Asian ancestry controls
Region14q31.3
Chromosome idchr14
Chromosome position88006251
Reported geneNR
Mapped geneGPR65
Upstream gene id
Downstream gene id
SNP gene ids8477
Upstream gene distance
Downstream gene distance
SNP risk allelers8005161-A
SNPsrs8005161
Merged0
SNP id current8005161
Contextintron_variant
Intergenic0
Allele frequency0.08653
P value0.000000003
Pvalue mlog8.52287874528033
P value text(EA)
Or beta1.1371082
%95 Ci[1.09-1.18]
PlatformAffymetrix, Illumina [~ 9000000] (imputed)
CNVN
Mapped traitulcerative colitis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000729
Study accessionGCST003045
PubMed ID26192919
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26192919
StudyAssociation analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
Disease/TraitCrohn__s disease
Initial sample5,956 European ancestry cases, 14,927 European ancestry controls
Replication sample14,594 European ancestry cases, 26,715 European ancestry controls, 151 Iranian ancestry cases, 342 Iranian ancestry controls, 184 Indian ancestry cases, 990 Indian ancestry controls, 1,690 East Asian ancestry cases, 3,719 East Asian ancestry controls
Region14q31.3
Chromosome idchr14
Chromosome position88006251
Reported geneNR
Mapped geneGPR65
Upstream gene id
Downstream gene id
SNP gene ids8477
Upstream gene distance
Downstream gene distance
SNP risk allelers8005161-A
SNPsrs8005161
Merged0
SNP id current8005161
Contextintron_variant
Intergenic0
Allele frequency0.08653
P value0.00000000000009
Pvalue mlog13.0457574905606
P value text(EA)
Or beta1.1677363
%95 Ci[1.13-1.21]
PlatformAffymetrix, Illumina [~ 9000000] (imputed)
CNVN
Mapped traitCrohn__s disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000384
Study accessionGCST003044