SNP Detail For rs7964748
1.Mapping Information
Human SNP ID rs7964748
Human chromosome chr12
Human SNP position 102571551
Pig chromosome chr5
Pig SNP position 85607850
2.Annotation Information
PubMed ID23400010
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/23400010
StudyGenome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
Disease/TraitThiazide-induced adverse metabolic effects in hypertensive patients
Initial sample425 European ancestry cases, 342 African American cases
Replication sampleNA
Region12q23.2
Chromosome idchr12
Chromosome position102571551
Reported geneIGF1
Mapped geneIGF1 - LINC00485
Upstream gene id3479
Downstream gene id283432
SNP gene ids
Upstream gene distance89765
Downstream gene distance237732
SNP risk allelers7964748-G
SNPsrs7964748
Merged0
SNP id current7964748
Contextintergenic_variant
Intergenic1
Allele frequency0.28
P value0.000003
Pvalue mlog5.52287874528033
P value text(AA-glucose response)
Or beta4.06
%95 Ci[2.37-5.75] mg/dL increase
PlatformAffymetrix, Illumina [> 2000000] (imputed)
CNVN
Mapped traitresponse to hydrochlorothiazide, fasting blood glucose measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005202, http://www.ebi.ac.uk/efo/EFO_0004465
Study accessionGCST001859