SNP Detail For rs7927894
1.Mapping Information
Human SNP ID rs7927894
Human chromosome chr11
Human SNP position 76590272
Pig chromosome chr9
Pig SNP position 11854294
2.Annotation Information
PubMed ID18587394
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/18587394
StudyGenome-wide association defines more than 30 distinct susceptibility loci for Crohn__s disease.
Disease/TraitCrohn__s disease
Initial sample3,230 European ancestry cases, 4,829 European ancestry controls
Replication sample1,339 European ancestry trios, 2,325 European ancestry cases, 1,809 European ancestry controls
Region11q13.5
Chromosome idchr11
Chromosome position76590272
Reported geneC11orf30
Mapped geneC11orf30 - LOC101928813
Upstream gene id56946
Downstream gene id101928813
SNP gene ids
Upstream gene distance37373
Downstream gene distance17879
SNP risk allelers7927894-T
SNPsrs7927894
Merged0
SNP id current7927894
Contextupstream_gene_variant
Intergenic1
Allele frequency0.39
P value0.000000001
Pvalue mlog9
P value text
Or beta1.16
%95 Ci[NR]
PlatformAffymetrix, Illumina [635547] (imputed)
CNVN
Mapped traitCrohn__s disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000384
Study accessionGCST000207
PubMed ID19349984
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19349984
StudyA common variant on chromosome 11q13 is associated with atopic dermatitis.
Disease/TraitAtopic dermatitis
Initial sample939 European ancestry cases, 975 European ancestry controls, 1,097 European ancestry individuals from 270 families
Replication sample2,637 European ancestry cases, 3,957 European ancestry controls
Region11q13.5
Chromosome idchr11
Chromosome position76590272
Reported geneC11orf30
Mapped geneC11orf30 - LOC101928813
Upstream gene id56946
Downstream gene id101928813
SNP gene ids
Upstream gene distance37373
Downstream gene distance17879
SNP risk allelers7927894-A
SNPsrs7927894
Merged0
SNP id current7927894
Contextupstream_gene_variant
Intergenic1
Allele frequency0.36
P value0.0000000008
Pvalue mlog9.09691001300805
P value text
Or beta1.22
%95 Ci[1.15-1.30]
PlatformAffymetrix [342303]
CNVN
Mapped traitatopic eczema
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000274
Study accessionGCST000374
PubMed ID26482879
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26482879
StudyMulti-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
Disease/TraitAtopic dermatitis
Initial sample18,900 European ancestry cases, 1,472 Japanese ancestry cases, 422 African American cases, 300 Latino cases, 305 cases, 84,166 European ancestry controls, 7,966 Japanese ancestry controls, 844 African American controls, 1,592 Latino controls, 896 controls
Replication sample30,588 European ancestry cases, 459 African American cases, 1,012 Chinese ancestry cases, 226,537 European ancestry controls, 729 African American controls, 1,362 Chinese ancestry controls
Region11q13.5
Chromosome idchr11
Chromosome position76590272
Reported geneC11orf30
Mapped geneC11orf30 - LOC101928813
Upstream gene id56946
Downstream gene id101928813
SNP gene ids
Upstream gene distance37373
Downstream gene distance17879
SNP risk allelers7927894-T
SNPsrs7927894
Merged0
SNP id current7927894
Contextupstream_gene_variant
Intergenic1
Allele frequencyNR
P value0.000000003
Pvalue mlog8.52287874528033
P value text(EA, fixed effects)
Or beta1.08
%95 Ci[1.05-1.10]
PlatformIllumina [15539996] (imputed)
CNVN
Mapped traitatopic eczema
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000274
Study accessionGCST003184