SNP Detail For rs7920721
1.Mapping Information
Human SNP ID rs7920721
Human chromosome chr10
Human SNP position 11678309
Pig chromosome chr10
Pig SNP position 65887092
2.Annotation Information
PubMed ID24162737
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24162737
StudyMeta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer__s disease.
Disease/TraitAlzheimer__s disease (late onset)
Initial sample17,008 European ancestry cases, 37,154 European ancestry controls
Replication sample8,572 European ancestry cases, 11,312 European ancestry controls
Region10p14
Chromosome idchr10
Chromosome position11678309
Reported geneECHDC3
Mapped geneLOC105376413, LOC105376412
Upstream gene id
Downstream gene id
SNP gene ids105376413, 105376412
Upstream gene distance
Downstream gene distance
SNP risk allelers7920721-G
SNPsrs7920721
Merged0
SNP id current7920721
Contextupstream_gene_variant
Intergenic0
Allele frequency0.387
P value0.0000003
Pvalue mlog6.52287874528033
P value text
Or beta1.07
%95 Ci[1.04-1.10]
PlatformIllumina [7055881] (imputed)
CNVN
Mapped traitAlzheimers disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000249
Study accessionGCST002245
PubMed ID25778476
JournalMol Psychiatry
Linkwww.ncbi.nlm.nih.gov/pubmed/25778476
StudyA novel Alzheimer disease locus located near the gene encoding tau protein.
Disease/TraitAlzheimer__s disease in APOE e4- carriers
Initial sample7,184 cases, 26,968 controls
Replication sample718 European ancestry cases, 1,699 European ancestry controls
Region10p14
Chromosome idchr10
Chromosome position11678309
Reported geneUSP6NL, ECHDC3
Mapped geneLOC105376413, LOC105376412
Upstream gene id
Downstream gene id
SNP gene ids105376413, 105376412
Upstream gene distance
Downstream gene distance
SNP risk allelers7920721-G
SNPsrs7920721
Merged0
SNP id current7920721
Contextupstream_gene_variant
Intergenic0
Allele frequency0.38
P value0.000003
Pvalue mlog5.52287874528033
P value text
Or beta1.12
%95 Ci[1.07-1.17]
PlatformNR [NR]
CNVN
Mapped traitAlzheimers disease
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000249
Study accessionGCST002817