SNP Detail For rs7818688
1.Mapping Information
Human SNP ID rs7818688
Human chromosome chr8
Human SNP position 95011854
Pig chromosome chr4
Pig SNP position 44933554
2.Annotation Information
PubMed ID25710658
JournalJAMA
Linkwww.ncbi.nlm.nih.gov/pubmed/25710658
StudyAssociation of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.
Disease/TraitVincristine-induced peripheral neuropathy in acute lymphoblastic leukemia
Initial sample53 European ancestry cases with peripheral neuropathy, 156 cases without peripheral neuropathy, 10 African ancestry cases with peripheral neuropathy, 33 African ancestry cases without peripheral neuropathy, 1 Asian ancestry case with peripheral neuropathy
Replication sampleNA
Region8q22.1
Chromosome idchr8
Chromosome position95011854
Reported geneNDUFAF6
Mapped geneNDUFAF6
Upstream gene id
Downstream gene id
SNP gene ids137682
Upstream gene distance
Downstream gene distance
SNP risk allelers7818688-?
SNPsrs7818688
Merged0
SNP id current7818688
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.00000004
Pvalue mlog7.39794000867203
P value text
Or beta4.26
%95 Ci[2.45-7.42]
PlatformAffymetrix [1576016] (imputed)
CNVN
Mapped traitperipheral neuropathy, acute lymphoblastic leukemia, response to vincristine
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003100, http://www.ebi.ac.uk/efo/EFO_0000220, http://www.ebi.ac.uk/efo/EFO_0006950
Study accessionGCST002792