SNP Detail For rs7759742
1.Mapping Information
Human SNP ID rs7759742
Human chromosome chr6
Human SNP position 32413959
Pig chromosome chr7
Pig SNP position 29024099
2.Annotation Information
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region6p21.32
Chromosome idchr6
Chromosome position32413959
Reported geneBTNL2
Mapped geneBTNL2 - HLA-DRA
Upstream gene id56244
Downstream gene id3122
SNP gene ids
Upstream gene distance5080
Downstream gene distance25883
SNP risk allelers7759742-A
SNPsrs7759742
Merged0
SNP id current7759742
Contextintergenic_variant
Intergenic1
Allele frequency0.5107
P value0.0000002
Pvalue mlog6.69897000433601
P value text(EA, women)
Or beta0.0237
%95 Ci[0.015-0.033] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region6p21.32
Chromosome idchr6
Chromosome position32413959
Reported geneBTNL2
Mapped geneBTNL2 - HLA-DRA
Upstream gene id56244
Downstream gene id3122
SNP gene ids
Upstream gene distance5080
Downstream gene distance25883
SNP risk allelers7759742-A
SNPsrs7759742
Merged0
SNP id current7759742
Contextintergenic_variant
Intergenic1
Allele frequency0.5106
P value0.000005
Pvalue mlog5.30102999566398
P value text(EA, men)
Or beta0.0226
%95 Ci[0.013-0.032] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region6p21.32
Chromosome idchr6
Chromosome position32413959
Reported geneBTNL2
Mapped geneBTNL2 - HLA-DRA
Upstream gene id56244
Downstream gene id3122
SNP gene ids
Upstream gene distance5080
Downstream gene distance25883
SNP risk allelers7759742-A
SNPsrs7759742
Merged0
SNP id current7759742
Contextintergenic_variant
Intergenic1
Allele frequency0.511
P value0.00000000004
Pvalue mlog10.397940008672
P value text(EA)
Or beta0.0226
%95 Ci[0.016-0.029] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region6p21.32
Chromosome idchr6
Chromosome position32413959
Reported geneBTNL2
Mapped geneBTNL2 - HLA-DRA
Upstream gene id56244
Downstream gene id3122
SNP gene ids
Upstream gene distance5080
Downstream gene distance25883
SNP risk allelers7759742-A
SNPsrs7759742
Merged0
SNP id current7759742
Contextintergenic_variant
Intergenic1
Allele frequency0.5154
P value0.000004
Pvalue mlog5.39794000867203
P value text(men)
Or beta0.0223
%95 Ci[0.013-0.032] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region6p21.32
Chromosome idchr6
Chromosome position32413959
Reported geneBTNL2
Mapped geneBTNL2 - HLA-DRA
Upstream gene id56244
Downstream gene id3122
SNP gene ids
Upstream gene distance5080
Downstream gene distance25883
SNP risk allelers7759742-A
SNPsrs7759742
Merged0
SNP id current7759742
Contextintergenic_variant
Intergenic1
Allele frequency0.5158
P value0.00000005
Pvalue mlog7.30102999566398
P value text(women)
Or beta0.0241
%95 Ci[0.015-0.033] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region6p21.32
Chromosome idchr6
Chromosome position32413959
Reported geneBTNL2
Mapped geneBTNL2 - HLA-DRA
Upstream gene id56244
Downstream gene id3122
SNP gene ids
Upstream gene distance5080
Downstream gene distance25883
SNP risk allelers7759742-A
SNPsrs7759742
Merged0
SNP id current7759742
Contextintergenic_variant
Intergenic1
Allele frequency0.517
P value0.00000000002
Pvalue mlog10.698970004336
P value text
Or beta0.0224
%95 Ci[0.016-0.029] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782