SNP Detail For rs7754840
1.Mapping Information
Human SNP ID rs7754840
Human chromosome chr6
Human SNP position 20661019
Pig chromosome chr7
Pig SNP position 16933777
2.Annotation Information
PubMed ID17463246
JournalScience
Linkwww.ncbi.nlm.nih.gov/pubmed/17463246
StudyGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
Disease/TraitType 2 diabetes
Initial sample1,464 European ancestry cases, 1,467 European ancestry controls
Replication sample5,065 European ancestry cases, 5,785 European ancestry controls
Region6p22.3
Chromosome idchr6
Chromosome position20661019
Reported geneCDKAL1
Mapped geneCDKAL1
Upstream gene id
Downstream gene id
SNP gene ids54901
Upstream gene distance
Downstream gene distance
SNP risk allelers7754840-C
SNPsrs7754840
Merged0
SNP id current7754840
Contextintron_variant
Intergenic0
Allele frequency0.31
P value0.00000000004
Pvalue mlog10.397940008672
P value text(DGI+FUSION+WTCCC)
Or beta1.12
%95 Ci[1.08-1.16]
PlatformAffymetrix [386731]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000028
PubMed ID17463248
JournalScience
Linkwww.ncbi.nlm.nih.gov/pubmed/17463248
StudyA genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
Disease/TraitType 2 diabetes
Initial sample1,161 European ancestry cases, 1,174 European ancestry controls
Replication sample1,215 European ancestry cases, 1,258 European ancestry controls
Region6p22.3
Chromosome idchr6
Chromosome position20661019
Reported geneCDKAL1
Mapped geneCDKAL1
Upstream gene id
Downstream gene id
SNP gene ids54901
Upstream gene distance
Downstream gene distance
SNP risk allelers7754840-C
SNPsrs7754840
Merged0
SNP id current7754840
Contextintron_variant
Intergenic0
Allele frequency0.36
P value0.00000000004
Pvalue mlog10.397940008672
P value text(DGI+FUSION+WTCCC)
Or beta1.12
%95 Ci[1.08-1.16]
PlatformIllumina [315635]
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST000024
PubMed ID22233651
JournalDiabetes
Linkwww.ncbi.nlm.nih.gov/pubmed/22233651
StudyA genome-wide association study of gestational diabetes mellitus in Korean women.
Disease/TraitDiabetes (gestational)
Initial sample468 Korean ancestry cases, 1,242 Korean ancestry controls
Replication sample931 Korean ancestry cases, 783 Korean ancestry controls
Region6p22.3
Chromosome idchr6
Chromosome position20661019
Reported geneCDKAL1
Mapped geneCDKAL1
Upstream gene id
Downstream gene id
SNP gene ids54901
Upstream gene distance
Downstream gene distance
SNP risk allelers7754840-C
SNPsrs7754840
Merged0
SNP id current7754840
Contextintron_variant
Intergenic0
Allele frequency0.445
P value0.0000000000000007
Pvalue mlog15.1549019599857
P value text
Or beta1.518
%95 Ci[1.372-1.680]
PlatformAffymetrix [2188613] (imputed)
CNVN
Mapped traitgestational diabetes
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004593
Study accessionGCST001375
PubMed ID22961080
JournalDiabetes
Linkwww.ncbi.nlm.nih.gov/pubmed/22961080
StudyA genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
Disease/TraitType 2 diabetes
Initial sample1,839 Han Chinese ancestry cases, 1,873 Han Chinese ancestry controls
Replication sample15,979 East Asian ancestry cases, 19,360 East Asian ancestry controls, 794 Malay ancestry cases, 1,240 Malay ancestry controls, 159 Filipino ancestry cases, 1,624 Filipino ancestry controls
Region6p22.3
Chromosome idchr6
Chromosome position20661019
Reported geneCDKAL1
Mapped geneCDKAL1
Upstream gene id
Downstream gene id
SNP gene ids54901
Upstream gene distance
Downstream gene distance
SNP risk allelers7754840-C
SNPsrs7754840
Merged0
SNP id current7754840
Contextintron_variant
Intergenic0
Allele frequency0.411
P value0.0000000007
Pvalue mlog9.15490195998574
P value text
Or beta1.35
%95 Ci[1.23-1.48]
PlatformIllumina [2234194] (imputed)
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST001666
PubMed ID23945395
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23945395
StudyGenome-wide association study identifies three novel loci for type 2 diabetes.
Disease/TraitType 2 diabetes
Initial sample5,976 Japanese ancestry cases, 20,829 Japanese ancestry controls
Replication sample24,416 East Asian ancestry cases, 13,985 East Asian ancestry controls
Region6p22.3
Chromosome idchr6
Chromosome position20661019
Reported geneCDKAL1
Mapped geneCDKAL1
Upstream gene id
Downstream gene id
SNP gene ids54901
Upstream gene distance
Downstream gene distance
SNP risk allelers7754840-C
SNPsrs7754840
Merged0
SNP id current7754840
Contextintron_variant
Intergenic0
Allele frequency0.42
P value0.0000000000002
Pvalue mlog12.698970004336
P value text
Or beta1.18
%95 Ci[1.13-1.23]
PlatformIllumina [6209637] (imputed)
CNVN
Mapped traittype II diabetes mellitus
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0001360
Study accessionGCST002128