SNP Detail For rs7752903
1.Mapping Information
Human SNP ID rs7752903
Human chromosome chr6
Human SNP position 137906227
Pig chromosome chr1
Pig SNP position 29813998
2.Annotation Information
PubMed ID24390342
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/24390342
StudyGenetics of rheumatoid arthritis contributes to biology and drug discovery.
Disease/TraitRheumatoid arthritis
Initial sampleup to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls
Replication sampleup to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls
Region6q23.3
Chromosome idchr6
Chromosome position137906227
Reported geneTNFAIP3
Mapped geneTNFAIP3 - LOC105378020
Upstream gene id7128
Downstream gene id105378020
SNP gene ids
Upstream gene distance22913
Downstream gene distance38815
SNP risk allelers7752903-G
SNPsrs7752903
Merged0
SNP id current7752903
Contextregulatory_region_variant
Intergenic1
Allele frequency0.04
P value2E-29
Pvalue mlog28.698970004336
P value text
Or beta1.38
%95 Ci[1.31-1.46]
PlatformAffymetrix, Illumina [up to 9739303] (imputed)
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST002318
PubMed ID24390342
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/24390342
StudyGenetics of rheumatoid arthritis contributes to biology and drug discovery.
Disease/TraitRheumatoid arthritis
Initial sampleup to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls
Replication sampleup to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls
Region6q23.3
Chromosome idchr6
Chromosome position137906227
Reported geneTNFAIP3
Mapped geneTNFAIP3 - LOC105378020
Upstream gene id7128
Downstream gene id105378020
SNP gene ids
Upstream gene distance22913
Downstream gene distance38815
SNP risk allelers7752903-G
SNPsrs7752903
Merged0
SNP id current7752903
Contextregulatory_region_variant
Intergenic1
Allele frequency0.03
P value2E-20
Pvalue mlog19.698970004336
P value text(EA)
Or beta1.41
%95 Ci[1.31-1.52]
PlatformAffymetrix, Illumina [up to 9739303] (imputed)
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST002318
PubMed ID24390342
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/24390342
StudyGenetics of rheumatoid arthritis contributes to biology and drug discovery.
Disease/TraitRheumatoid arthritis
Initial sampleup to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls
Replication sampleup to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls
Region6q23.3
Chromosome idchr6
Chromosome position137906227
Reported geneTNFAIP3
Mapped geneTNFAIP3 - LOC105378020
Upstream gene id7128
Downstream gene id105378020
SNP gene ids
Upstream gene distance22913
Downstream gene distance38815
SNP risk allelers7752903-G
SNPsrs7752903
Merged0
SNP id current7752903
Contextregulatory_region_variant
Intergenic1
Allele frequency0.07
P value0.00000000007
Pvalue mlog10.1549019599857
P value text(East Asian)
Or beta1.34
%95 Ci[1.23-1.46]
PlatformAffymetrix, Illumina [up to 9739303] (imputed)
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST002318