Human SNP ID | rs769449 |
---|---|
Human chromosome | chr19 |
Human SNP position | 44906745 |
Pig chromosome | chr6 |
Pig SNP position | 47270088 |
PubMed ID | 18439548 |
---|---|
Journal | Am J Hum Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/18439548 |
Study | Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women__s Genome Health Study. |
Disease/Trait | C-reactive protein |
Initial sample | 6,345 European ancestry female individuals |
Replication sample | NA |
Region | 19q13.32 |
Chromosome id | chr19 |
Chromosome position | 44906745 |
Reported gene | APOE |
Mapped gene | APOE |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 348 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs769449-? |
SNPs | rs769449 |
Merged | 0 |
SNP id current | 769449 |
Context | non_coding_transcript_exon_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 9E-21 |
Pvalue mlog | 20.0457574905606 |
P value text | |
Or beta | 0.26 |
%95 Ci | [NR] mg/dl decrease |
Platform | Illumina [336108] |
CNV | N |
Mapped trait | C-reactive protein measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004458 |
Study accession | GCST000178 |
PubMed ID | 24468470 |
Journal | Neurobiol Aging |
Link | www.ncbi.nlm.nih.gov/pubmed/24468470 |
Study | Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study. |
Disease/Trait | Cognitive decline (age-related) |
Initial sample | 5,765 European ancestry individuals, 890 African American individuals |
Replication sample | NA |
Region | 19q13.32 |
Chromosome id | chr19 |
Chromosome position | 44906745 |
Reported gene | APOE |
Mapped gene | APOE |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 348 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs769449-? |
SNPs | rs769449 |
Merged | 0 |
SNP id current | 769449 |
Context | non_coding_transcript_exon_variant |
Intergenic | 0 |
Allele frequency | 0.116 |
P value | 5E-19 |
Pvalue mlog | 18.3010299956639 |
P value text | (EA) |
Or beta | 0.0315 |
%95 Ci | [0.02457-0.03835] unit decrease |
Platform | Illumina [1530316] |
CNV | N |
Mapped trait | cognitive decline |
Mapped trait URI | http://purl.obolibrary.org/obo/HP_0001268 |
Study accession | GCST002320 |
PubMed ID | 23562540 |
Journal | Neuron |
Link | www.ncbi.nlm.nih.gov/pubmed/23562540 |
Study | GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer__s disease. |
Disease/Trait | Alzheimer__s disease biomarkers |
Initial sample | 591 European ancestry cases, 687 European ancestry controls |
Replication sample | |
Region | 19q13.32 |
Chromosome id | chr19 |
Chromosome position | 44906745 |
Reported gene | APOE, TOMM40 |
Mapped gene | APOE |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 348 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs769449-A |
SNPs | rs769449 |
Merged | 0 |
SNP id current | 769449 |
Context | non_coding_transcript_exon_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.0000000000000002 |
Pvalue mlog | 15.698970004336 |
P value text | (tau) |
Or beta | 0.082 |
%95 Ci | [NR] unit increase |
Platform | Illumina [5815690] (imputed) |
CNV | N |
Mapped trait | Alzheimers disease, t-tau measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000249, http://www.ebi.ac.uk/efo/EFO_0004760 |
Study accession | GCST001951 |
PubMed ID | 23562540 |
Journal | Neuron |
Link | www.ncbi.nlm.nih.gov/pubmed/23562540 |
Study | GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer__s disease. |
Disease/Trait | Alzheimer__s disease biomarkers |
Initial sample | 591 European ancestry cases, 687 European ancestry controls |
Replication sample | |
Region | 19q13.32 |
Chromosome id | chr19 |
Chromosome position | 44906745 |
Reported gene | APOE, TOMM40 |
Mapped gene | APOE |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 348 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs769449-A |
SNPs | rs769449 |
Merged | 0 |
SNP id current | 769449 |
Context | non_coding_transcript_exon_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.000000000000000002 |
Pvalue mlog | 17.698970004336 |
P value text | (ptau) |
Or beta | 0.091 |
%95 Ci | [NR] unit increase |
Platform | Illumina [5815690] (imputed) |
CNV | N |
Mapped trait | p-tau measurement, Alzheimers disease |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004763, http://www.ebi.ac.uk/efo/EFO_0000249 |
Study accession | GCST001951 |
PubMed ID | 26421299 |
Journal | Biomed Res Int |
Link | www.ncbi.nlm.nih.gov/pubmed/26421299 |
Study | Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort. |
Disease/Trait | Cingulate cortical amyloid beta load |
Initial sample | 215 European ancestry early mild cognitive impairment cases, 152 European ancestry late mild cognitive impairment cases, 45 European ancestry Alzheimer disease cases, 190 European ancestry controls |
Replication sample | NA |
Region | 19q13.32 |
Chromosome id | chr19 |
Chromosome position | 44906745 |
Reported gene | APOE |
Mapped gene | APOE |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 348 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs769449-? |
SNPs | rs769449 |
Merged | 0 |
SNP id current | 769449 |
Context | non_coding_transcript_exon_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.00000000000000005 |
Pvalue mlog | 16.3010299956639 |
P value text | |
Or beta | |
%95 Ci | |
Platform | Illumina [582718] |
CNV | N |
Mapped trait | amyloid-beta measurement, cingulate cortex measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005194, http://www.ebi.ac.uk/efo/EFO_0007738 |
Study accession | GCST003113 |