SNP Detail For rs7582701
1.Mapping Information
Human SNP ID rs7582701
Human chromosome chr2
Human SNP position 46323630
Pig chromosome chr3
Pig SNP position 100308327
2.Annotation Information
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region2p21
Chromosome idchr2
Chromosome position46323630
Reported geneNR
Mapped geneLOC105374583, EPAS1
Upstream gene id
Downstream gene id
SNP gene ids105374583, 2034
Upstream gene distance
Downstream gene distance
SNP risk allelers7582701-C
SNPsrs7582701
Merged0
SNP id current7582701
Contextintron_variant
Intergenic0
Allele frequency0.0373370440481498
P value0.000001
Pvalue mlog6
P value text(IGP69)
Or beta0.4547
%95 Ci[0.27-0.64] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region2p21
Chromosome idchr2
Chromosome position46323630
Reported geneNR
Mapped geneLOC105374583, EPAS1
Upstream gene id
Downstream gene id
SNP gene ids105374583, 2034
Upstream gene distance
Downstream gene distance
SNP risk allelers7582701-C
SNPsrs7582701
Merged0
SNP id current7582701
Contextintron_variant
Intergenic0
Allele frequency0.037394344593387
P value0.000004
Pvalue mlog5.39794000867203
P value text(IGP74)
Or beta0.4338
%95 Ci[0.25-0.62] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region2p21
Chromosome idchr2
Chromosome position46323630
Reported geneNR
Mapped geneLOC105374583, EPAS1
Upstream gene id
Downstream gene id
SNP gene ids105374583, 2034
Upstream gene distance
Downstream gene distance
SNP risk allelers7582701-C
SNPsrs7582701
Merged0
SNP id current7582701
Contextintron_variant
Intergenic0
Allele frequency0.0373185578689255
P value0.000002
Pvalue mlog5.69897000433601
P value text(IGP75)
Or beta0.4488
%95 Ci[0.27-0.63] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region2p21
Chromosome idchr2
Chromosome position46323630
Reported geneNR
Mapped geneLOC105374583, EPAS1
Upstream gene id
Downstream gene id
SNP gene ids105374583, 2034
Upstream gene distance
Downstream gene distance
SNP risk allelers7582701-C
SNPsrs7582701
Merged0
SNP id current7582701
Contextintron_variant
Intergenic0
Allele frequency0.0372783807743658
P value0.000004
Pvalue mlog5.39794000867203
P value text(IGP76)
Or beta0.4309
%95 Ci[0.25-0.61] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848