SNP Detail For rs7555523
1.Mapping Information
Human SNP ID rs7555523
Human chromosome chr1
Human SNP position 165749742
Pig chromosome chr4
Pig SNP position 92640116
2.Annotation Information
PubMed ID22570627
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22570627
StudyCommon genetic determinants of intraocular pressure and primary open-angle glaucoma.
Disease/TraitIntraocular pressure
Initial sample11,972 European ancestry individuals
Replication sample7,482 European ancestry individuals
Region1q24.1
Chromosome idchr1
Chromosome position165749742
Reported geneTMCO1
Mapped geneTMCO1
Upstream gene id
Downstream gene id
SNP gene ids54499
Upstream gene distance
Downstream gene distance
SNP risk allelers7555523-C
SNPsrs7555523
Merged0
SNP id current7555523
Contextintron_variant
Intergenic0
Allele frequency0.12
P value0.00000002
Pvalue mlog7.69897000433601
P value text
Or beta0.28
%95 Ci[0.18-0.37] mmHg increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitintraocular pressure measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004695
Study accessionGCST001506
PubMed ID25173106
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25173106
StudyGenome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
Disease/TraitIntraocular pressure
Initial sample7,738 Asian ancestry individuals, 27,558 European ancestry individuals
Replication sampleNA
Region1q24.1
Chromosome idchr1
Chromosome position165749742
Reported geneTMCO1
Mapped geneTMCO1
Upstream gene id
Downstream gene id
SNP gene ids54499
Upstream gene distance
Downstream gene distance
SNP risk allelers7555523-C
SNPsrs7555523
Merged0
SNP id current7555523
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.000000002
Pvalue mlog8.69897000433601
P value text
Or beta0.235
%95 Ci[0.16-0.31] mm Hg increase
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitintraocular pressure measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004695
Study accessionGCST002580