SNP Detail For rs7553007
1.Mapping Information
Human SNP ID rs7553007
Human chromosome chr1
Human SNP position 159728759
Pig chromosome chr4
Pig SNP position 98737937
2.Annotation Information
PubMed ID19567438
JournalJAMA
Linkwww.ncbi.nlm.nih.gov/pubmed/19567438
StudyGenetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
Disease/TraitC-reactive protein
Initial sample17,967 European ancestry and Indian Asian ancestry individuals
Replication sample13,615 European ancestry and Indian Asian ancestry Individuals
Region1q23.2
Chromosome idchr1
Chromosome position159728759
Reported geneCRP
Mapped geneCRP - RPL27P2
Upstream gene id1401
Downstream gene id646446
SNP gene ids
Upstream gene distance14150
Downstream gene distance30385
SNP risk allelers7553007-A
SNPsrs7553007
Merged0
SNP id current7553007
Contextintergenic_variant
Intergenic1
Allele frequencyNR
P value8E-44
Pvalue mlog43.096910013008
P value text
Or beta20.7
%95 Ci[18.9-23.4] % decrease
PlatformAffymetrix, Illumina, Perlegen [~ 1400000] (imputed)
CNVN
Mapped traitC-reactive protein measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004458
Study accessionGCST000430
PubMed ID22939635
JournalAm J Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22939635
StudyGenome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
Disease/TraitC-reactive protein
Initial sample8,280 African American female individuals, 3,548 Hispanic female individuals
Replication sample3,787 African American female individuals, 3,548 Hispanic female individuals, 5,656 European ancestry individuals
Region1q23.2
Chromosome idchr1
Chromosome position159728759
Reported geneCRP
Mapped geneCRP - RPL27P2
Upstream gene id1401
Downstream gene id646446
SNP gene ids
Upstream gene distance14150
Downstream gene distance30385
SNP risk allelers7553007-G
SNPsrs7553007
Merged0
SNP id current7553007
Contextintergenic_variant
Intergenic1
Allele frequency0.344
P value0.000000001
Pvalue mlog9
P value text(HA women)
Or beta0.129
%95 Ci[0.078-0.180] unit increase
PlatformAffymetrix [up to 2203609] (imputed)
CNVN
Mapped traitC-reactive protein measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004458
Study accessionGCST001650
PubMed ID22939635
JournalAm J Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22939635
StudyGenome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
Disease/TraitC-reactive protein
Initial sample8,280 African American female individuals, 3,548 Hispanic female individuals
Replication sample3,787 African American female individuals, 3,548 Hispanic female individuals, 5,656 European ancestry individuals
Region1q23.2
Chromosome idchr1
Chromosome position159728759
Reported geneFCER1A, DUSP23, OR10J1, APCS, DARC, IFI16, OR10J5, CRP, OR10J3, OLFML2B, FCRL6
Mapped geneCRP - RPL27P2
Upstream gene id1401
Downstream gene id646446
SNP gene ids
Upstream gene distance14150
Downstream gene distance30385
SNP risk allelers7553007-T
SNPsrs7553007
Merged0
SNP id current7553007
Contextintergenic_variant
Intergenic1
Allele frequency0.228
P value1E-37
Pvalue mlog37
P value text(AA women)
Or beta0.272
%95 Ci[0.23-0.31] unit decrease
PlatformAffymetrix [up to 2203609] (imputed)
CNVN
Mapped traitC-reactive protein measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004458
Study accessionGCST001650
PubMed ID24763700
JournalPLoS One
Linkwww.ncbi.nlm.nih.gov/pubmed/24763700
StudyNew variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis.
Disease/TraitC-reactive protein levels
Initial sample7,626 Korean ancestry individuals
Replication sample903 Korean ancestry individuals
Region1q23.2
Chromosome idchr1
Chromosome position159728759
Reported geneCRP
Mapped geneCRP - RPL27P2
Upstream gene id1401
Downstream gene id646446
SNP gene ids
Upstream gene distance14150
Downstream gene distance30385
SNP risk allelers7553007-C
SNPsrs7553007
Merged0
SNP id current7553007
Contextintergenic_variant
Intergenic1
Allele frequency0.369
P value0.0000000000000002
Pvalue mlog15.698970004336
P value text
Or beta0.164
%95 Ci[NR] unit increase
PlatformAffymetrix [1219546] (imputed)
CNVN
Mapped traitC-reactive protein measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004458
Study accessionGCST002424