SNP Detail For rs7466269
1.Mapping Information
Human SNP ID rs7466269
Human chromosome chr9
Human SNP position 130588697
Pig chromosome chr1
Pig SNP position 304581721
2.Annotation Information
PubMed ID20881960
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/20881960
StudyHundreds of variants clustered in genomic loci and biological pathways affect human height.
Disease/TraitHeight
Initial sample133,653 European ancestry individuals
Replication sample50,074 European ancestry individuals
Region9q34.11
Chromosome idchr9
Chromosome position130588697
Reported geneFUBP3
Mapped geneFUBP3
Upstream gene id
Downstream gene id
SNP gene ids8939
Upstream gene distance
Downstream gene distance
SNP risk allelers7466269-A
SNPsrs7466269
Merged0
SNP id current7466269
Contextintron_variant
Intergenic0
Allele frequency0.64
P value0.00000000000000003
Pvalue mlog16.5228787452803
P value text
Or beta0.032
%95 Ci[NR] unit increase
PlatformAffymetrix, Illumina [2834208] (imputed)
CNVN
Mapped traitbody height
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004339
Study accessionGCST000817
PubMed ID24945404
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24945404
StudyPhenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
Disease/TraitBone mineral density (paediatric, total body less head)
Initial sample8,007 European ancestry children, 289 Surinamese ancestry children, 300 Turkish ancestry children, 232 Moroccan ancestry children, 588 children
Replication sampleNA
Region9q34.11
Chromosome idchr9
Chromosome position130588697
Reported geneFUBP3
Mapped geneFUBP3
Upstream gene id
Downstream gene id
SNP gene ids8939
Upstream gene distance
Downstream gene distance
SNP risk allelers7466269-A
SNPsrs7466269
Merged0
SNP id current7466269
Contextintron_variant
Intergenic0
Allele frequency0.65
P value0.00000003
Pvalue mlog7.52287874528033
P value text
Or beta0.084
%95 Ci[0.055-0.113] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitbone density
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003923
Study accessionGCST002494
PubMed ID24945404
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24945404
StudyPhenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
Disease/TraitBone mineral density (paediatric, lower limb)
Initial sample8,007 European ancestry children, 289 Surinamese ancestry children, 300 Turkish ancestry children, 232 Moroccan ancestry children, 588 children
Replication sampleNA
Region9q34.11
Chromosome idchr9
Chromosome position130588697
Reported geneFUBP3
Mapped geneFUBP3
Upstream gene id
Downstream gene id
SNP gene ids8939
Upstream gene distance
Downstream gene distance
SNP risk allelers7466269-A
SNPsrs7466269
Merged0
SNP id current7466269
Contextintron_variant
Intergenic0
Allele frequency0.65
P value0.00000002
Pvalue mlog7.69897000433601
P value text
Or beta0.087
%95 Ci[0.058-0.116] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitbone density
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003923
Study accessionGCST002492
PubMed ID24945404
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24945404
StudyPhenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
Disease/TraitBone mineral density (paediatric, lower limb)
Initial sample8,007 European ancestry children, 289 Surinamese ancestry children, 300 Turkish ancestry children, 232 Moroccan ancestry children, 588 children
Replication sampleNA
Region9q34.11
Chromosome idchr9
Chromosome position130588697
Reported geneFUBP3
Mapped geneFUBP3
Upstream gene id
Downstream gene id
SNP gene ids8939
Upstream gene distance
Downstream gene distance
SNP risk allelers7466269-A
SNPsrs7466269
Merged0
SNP id current7466269
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.000005
Pvalue mlog5.30102999566398
P value text(EA)
Or beta0.0793
%95 Ci[0.045-0.113] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitbone density
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003923
Study accessionGCST002492
PubMed ID23563607
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23563607
StudyGenome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Disease/TraitHeight
Initial sample8,097 European ancestry tall individuals, 8,099 European ancestry short individuals
Replication sample4,872 European ancestry tall individuals, 4,831 European ancestry short individuals
Region9q34.11
Chromosome idchr9
Chromosome position130588697
Reported geneFUBP3
Mapped geneFUBP3
Upstream gene id
Downstream gene id
SNP gene ids8939
Upstream gene distance
Downstream gene distance
SNP risk allelers7466269-A
SNPsrs7466269
Merged0
SNP id current7466269
Contextintron_variant
Intergenic0
Allele frequency0.64
P value0.0000000002
Pvalue mlog9.69897000433601
P value text
Or beta1.14
%95 Ci[NR]
PlatformAffymetrix, Illumina [~ 2800000] (imputed)
CNVN
Mapped traitbody height
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004339
Study accessionGCST001956
PubMed ID18391950
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/18391950
StudyIdentification of ten loci associated with height highlights new biological pathways in human growth.
Disease/TraitHeight
Initial sample15,821 European ancestry individuals
Replication sampleUp to 17,801 European ancestry individuals
Region9q34.11
Chromosome idchr9
Chromosome position130588697
Reported geneFUBP3
Mapped geneFUBP3
Upstream gene id
Downstream gene id
SNP gene ids8939
Upstream gene distance
Downstream gene distance
SNP risk allelers7466269-G
SNPsrs7466269
Merged0
SNP id current7466269
Contextintron_variant
Intergenic0
Allele frequency0.33
P value0.0000008
Pvalue mlog6.09691001300805
P value text
Or beta0.27
%95 Ci[0.38-0.69] cm decrease
PlatformAffymetrix, Illumina [2260683] (imputed)
CNVN
Mapped traitbody height
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004339
Study accessionGCST000176
PubMed ID25282103
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25282103
StudyDefining the role of common variation in the genomic and biological architecture of adult human height.
Disease/TraitHeight
Initial sample253,288 European ancestry individuals
Replication sample80,067 European ancestry individuals
Region9q34.11
Chromosome idchr9
Chromosome position130588697
Reported geneFUBP3
Mapped geneFUBP3
Upstream gene id
Downstream gene id
SNP gene ids8939
Upstream gene distance
Downstream gene distance
SNP risk allelers7466269-A
SNPsrs7466269
Merged0
SNP id current7466269
Contextintron_variant
Intergenic0
Allele frequency0.644
P value1E-27
Pvalue mlog27
P value text
Or beta0.033
%95 Ci[0.027-0.039] unit increase
PlatformAffymetrix, Illumina, Perlegen [2550858] (imputed)
CNVN
Mapped traitbody height
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004339
Study accessionGCST002647