SNP Detail For rs728996
1.Mapping Information
Human SNP ID rs728996
Human chromosome chr6
Human SNP position 51778216
Pig chromosome chr7
Pig SNP position 52064226
2.Annotation Information
PubMed ID23633212
JournalJ Clin Endocrinol Metab
Linkwww.ncbi.nlm.nih.gov/pubmed/23633212
StudyGenome-wide association of single-nucleotide polymorphisms with weight loss outcomes after Roux-en-Y gastric bypass surgery.
Disease/TraitWeight loss (gastric bypass surgery)
Initial sample86 European ancestry individuals with least EBWL, 89 European ancestry individuals with most EBWL
Replication sample164 European ancestry individuals with least EBWL, 169 European ancestry individuals with most EBWL
Region6p12.3
Chromosome idchr6
Chromosome position51778216
Reported genePKHD1
Mapped genePKHD1
Upstream gene id
Downstream gene id
SNP gene ids5314
Upstream gene distance
Downstream gene distance
SNP risk allelers728996-?
SNPsrs728996
Merged0
SNP id current728996
Contextintron_variant
Intergenic0
Allele frequency0.53
P value0.0000005
Pvalue mlog6.30102999566398
P value text
Or beta1.67
%95 Ci[NR]
PlatformAffymetrix [730767]
CNVN
Mapped traitgastric bypass, body weight loss
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005244, http://www.ebi.ac.uk/efo/EFO_0005245
Study accessionGCST001985
PubMed ID23633212
JournalJ Clin Endocrinol Metab
Linkwww.ncbi.nlm.nih.gov/pubmed/23633212
StudyGenome-wide association of single-nucleotide polymorphisms with weight loss outcomes after Roux-en-Y gastric bypass surgery.
Disease/TraitWeight loss (gastric bypass surgery)
Initial sample86 European ancestry individuals with least EBWL, 89 European ancestry individuals with most EBWL
Replication sample164 European ancestry individuals with least EBWL, 169 European ancestry individuals with most EBWL
Region6p12.2, 6p12.3
Chromosome idchr6;6;6;6;6;6
Chromosome position51809363;51778216;51790609;51778470;51808641;51791590
Reported genePKHD1
Mapped genePKHD1; PKHD1; PKHD1; PKHD1; PKHD1; PKHD1
Upstream gene id
Downstream gene id
SNP gene ids
Upstream gene distance
Downstream gene distance
SNP risk allelers1326589-?; rs728996-?; rs6458777-?; rs2894788-?; rs9296661-?; rs4715233-?
SNPsrs1326589; rs728996; rs6458777; rs2894788; rs9296661; rs4715233
Merged0
SNP id current
Contextintron_variant; intron_variant; intron_variant; intron_variant; intron_variant; intron_variant
Intergenic
Allele frequency0.39
P value0.00000005
Pvalue mlog7.30102999566398
P value text
Or beta10.9
%95 Ciunit decrease
PlatformAffymetrix [730767]
CNVN
Mapped traitgastric bypass, body weight loss
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005244, http://www.ebi.ac.uk/efo/EFO_0005245
Study accessionGCST001985