SNP Detail For rs7176508
1.Mapping Information
Human SNP ID rs7176508
Human chromosome chr15
Human SNP position 69726651
Pig chromosome chr1
Pig SNP position 185529522
2.Annotation Information
PubMed ID18758461
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/18758461
StudyA genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
Disease/TraitChronic lymphocytic leukemia
Initial sample505 European ancestry cases, 1,438 European ancestry controls
Replication sample1,024 European ancestry cases, 1,677 European ancestry controls
Region15q23
Chromosome idchr15
Chromosome position69726651
Reported geneintergenic
Mapped genePCAT29 - LINC00593
Upstream gene id104472713
Downstream gene id414926
SNP gene ids
Upstream gene distance30901
Downstream gene distance108583
SNP risk allelers7176508-A
SNPsrs7176508
Merged0
SNP id current7176508
Contextregulatory_region_variant
Intergenic1
Allele frequency0.37
P value0.000000000005
Pvalue mlog11.3010299956639
P value text
Or beta1.37
%95 Ci[1.26-1.50]
PlatformIllumina [345665]
CNVN
Mapped traitchronic lymphocytic leukemia
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000095
Study accessionGCST000224
PubMed ID22700719
JournalBlood
Linkwww.ncbi.nlm.nih.gov/pubmed/22700719
StudyCommon variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
Disease/TraitChronic lymphocytic leukemia
Initial sample1,121 European ancestry cases, 3,745 European ancestry controls
Replication sample861 European ancestry cases, 2,033 European ancestry controls
Region15q23
Chromosome idchr15
Chromosome position69726651
Reported geneNR
Mapped genePCAT29 - LINC00593
Upstream gene id104472713
Downstream gene id414926
SNP gene ids
Upstream gene distance30901
Downstream gene distance108583
SNP risk allelers7176508-A
SNPsrs7176508
Merged0
SNP id current7176508
Contextregulatory_region_variant
Intergenic1
Allele frequency0.37
P value0.00000000003
Pvalue mlog10.5228787452803
P value text
Or beta1.42
%95 Ci[1.28-1.58]
PlatformAffymetrix, Illumina [~ 1500000] (imputed)
CNVN
Mapped traitchronic lymphocytic leukemia
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000095
Study accessionGCST001570
PubMed ID23770605
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23770605
StudyGenome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
Disease/TraitChronic lymphocytic leukemia
Initial sample2,179 European ancestry cases, 6,221 European ancestry controls
Replication sample1,709 European ancestry cases, 6,318 European ancestry controls
Region15q23
Chromosome idchr15
Chromosome position69726651
Reported geneRPLP1
Mapped genePCAT29 - LINC00593
Upstream gene id104472713
Downstream gene id414926
SNP gene ids
Upstream gene distance30901
Downstream gene distance108583
SNP risk allelers7176508-A
SNPsrs7176508
Merged0
SNP id current7176508
Contextregulatory_region_variant
Intergenic1
Allele frequency0.39
P value0.00000000000000001
Pvalue mlog17
P value text
Or beta1.32
%95 Ci[NR]
PlatformIllumina [549934]
CNVN
Mapped traitchronic lymphocytic leukemia
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000095
Study accessionGCST002073
PubMed ID24292274
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24292274
StudyA genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
Disease/TraitChronic lymphocytic leukemia
Initial sample1,739 European ancestry cases, 5,199 European ancestry controls
Replication sample1,144 European ancestry cases, 3,151 European ancestry controls
Region15q23
Chromosome idchr15
Chromosome position69726651
Reported geneRPLP1
Mapped genePCAT29 - LINC00593
Upstream gene id104472713
Downstream gene id414926
SNP gene ids
Upstream gene distance30901
Downstream gene distance108583
SNP risk allelers7176508-A
SNPsrs7176508
Merged0
SNP id current7176508
Contextregulatory_region_variant
Intergenic1
Allele frequency0.38
P value0.000000000000000008
Pvalue mlog17.096910013008
P value text
Or beta1.42
%95 Ci[NR]
PlatformIllumina [450000] (imputed)
CNVN
Mapped traitchronic lymphocytic leukemia
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000095
Study accessionGCST002299