Human SNP ID | rs7147996 |
---|---|
Human chromosome | chr14 |
Human SNP position | 89930230 |
Pig chromosome | chr7 |
Pig SNP position | 118308845 |
PubMed ID | 23400010 |
---|---|
Journal | Pharmacogenomics J |
Link | www.ncbi.nlm.nih.gov/pubmed/23400010 |
Study | Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. |
Disease/Trait | Thiazide-induced adverse metabolic effects in hypertensive patients |
Initial sample | 425 European ancestry cases, 342 African American cases |
Replication sample | NA |
Region | 14q32.11 |
Chromosome id | chr14 |
Chromosome position | 89930230 |
Reported gene | c14ORF143 |
Mapped gene | EFCAB11 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 90141 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs7147996-A |
SNPs | rs7147996 |
Merged | 0 |
SNP id current | 7147996 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.12 |
P value | 0.000006 |
Pvalue mlog | 5.22184874961635 |
P value text | (AA-triglyceride response) |
Or beta | 28.09 |
%95 Ci | [15.96-40.22] mg/dL decrease |
Platform | Affymetrix, Illumina [> 2000000] (imputed) |
CNV | N |
Mapped trait | response to hydrochlorothiazide, triglyceride measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005202, http://www.ebi.ac.uk/efo/EFO_0004530 |
Study accession | GCST001859 |