SNP Detail For rs7147996
1.Mapping Information
Human SNP ID rs7147996
Human chromosome chr14
Human SNP position 89930230
Pig chromosome chr7
Pig SNP position 118308845
2.Annotation Information
PubMed ID23400010
JournalPharmacogenomics J
Linkwww.ncbi.nlm.nih.gov/pubmed/23400010
StudyGenome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
Disease/TraitThiazide-induced adverse metabolic effects in hypertensive patients
Initial sample425 European ancestry cases, 342 African American cases
Replication sampleNA
Region14q32.11
Chromosome idchr14
Chromosome position89930230
Reported genec14ORF143
Mapped geneEFCAB11
Upstream gene id
Downstream gene id
SNP gene ids90141
Upstream gene distance
Downstream gene distance
SNP risk allelers7147996-A
SNPsrs7147996
Merged0
SNP id current7147996
Contextintron_variant
Intergenic0
Allele frequency0.12
P value0.000006
Pvalue mlog5.22184874961635
P value text(AA-triglyceride response)
Or beta28.09
%95 Ci[15.96-40.22] mg/dL decrease
PlatformAffymetrix, Illumina [> 2000000] (imputed)
CNVN
Mapped traitresponse to hydrochlorothiazide, triglyceride measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005202, http://www.ebi.ac.uk/efo/EFO_0004530
Study accessionGCST001859