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SNP Detail For rs7141420
1.Mapping Information
| Human SNP ID | rs7141420 |
|---|---|
| Human chromosome | chr14 |
| Human SNP position | 79433111 |
| Pig chromosome | chr7 |
| Pig SNP position | 108614807 |
2.Annotation Information
| PubMed ID | 23563607 |
|---|---|
| Journal | Nat Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/23563607 |
| Study | Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. |
| Disease/Trait | Obesity |
| Initial sample | 93,015 European ancestry overweight individuals, 32,858 European ancestry class I obese individuals, 9,889 European ancestry class II obese individuals, 2,896 European ancestry class III obese individuals, up to 65,840 European ancestry controls |
| Replication sample | 65,332 European ancestry overweight individuals, 22,373 European ancestry class I obese individuals, 5,476 European ancestry class II obese individuals, 1,162 European ancestry class III obese individuals, up to 39,294 European ancestry controls |
| Region | 14q31.1 |
| Chromosome id | chr14 |
| Chromosome position | 79433111 |
| Reported gene | NRXN3 |
| Mapped gene | NRXN3 |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 9369 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs7141420-T |
| SNPs | rs7141420 |
| Merged | 0 |
| SNP id current | 7141420 |
| Context | intron_variant |
| Intergenic | 0 |
| Allele frequency | 0.52 |
| P value | 0.00000000000000001 |
| Pvalue mlog | 17 |
| P value text | (Obesity class I) |
| Or beta | 1.08 |
| %95 Ci | [NR] |
| Platform | Affymetrix, Illumina [~ 2800000] (imputed) |
| CNV | N |
| Mapped trait | obesity |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001073 |
| Study accession | GCST001953 |
| PubMed ID | 25673413 |
| Journal | Nature |
| Link | www.ncbi.nlm.nih.gov/pubmed/25673413 |
| Study | Genetic studies of body mass index yield new insights for obesity biology. |
| Disease/Trait | Body mass index |
| Initial sample | up to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals |
| Replication sample | up to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828 |
| Region | 14q31.1 |
| Chromosome id | chr14 |
| Chromosome position | 79433111 |
| Reported gene | NRXN3 |
| Mapped gene | NRXN3 |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 9369 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs7141420-T |
| SNPs | rs7141420 |
| Merged | 0 |
| SNP id current | 7141420 |
| Context | intron_variant |
| Intergenic | 0 |
| Allele frequency | 0.528 |
| P value | 0.00000006 |
| Pvalue mlog | 7.22184874961635 |
| P value text | (EA, men) |
| Or beta | 0.022 |
| %95 Ci | [0.014-0.03] kg/m2 increase |
| Platform | Affymetrix, Illumina [2550021] |
| CNV | N |
| Mapped trait | body mass index |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004340 |
| Study accession | GCST002783 |
| PubMed ID | 25673413 |
| Journal | Nature |
| Link | www.ncbi.nlm.nih.gov/pubmed/25673413 |
| Study | Genetic studies of body mass index yield new insights for obesity biology. |
| Disease/Trait | Body mass index |
| Initial sample | up to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals |
| Replication sample | up to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828 |
| Region | 14q31.1 |
| Chromosome id | chr14 |
| Chromosome position | 79433111 |
| Reported gene | NRXN3 |
| Mapped gene | NRXN3 |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 9369 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs7141420-T |
| SNPs | rs7141420 |
| Merged | 0 |
| SNP id current | 7141420 |
| Context | intron_variant |
| Intergenic | 0 |
| Allele frequency | 0.526 |
| P value | 0.00000000001 |
| Pvalue mlog | 11 |
| P value text | (EA, women) |
| Or beta | 0.026 |
| %95 Ci | [0.019-0.034] kg/m2 increase |
| Platform | Affymetrix, Illumina [2550021] |
| CNV | N |
| Mapped trait | body mass index |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004340 |
| Study accession | GCST002783 |
| PubMed ID | 25673413 |
| Journal | Nature |
| Link | www.ncbi.nlm.nih.gov/pubmed/25673413 |
| Study | Genetic studies of body mass index yield new insights for obesity biology. |
| Disease/Trait | Body mass index |
| Initial sample | up to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals |
| Replication sample | up to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828 |
| Region | 14q31.1 |
| Chromosome id | chr14 |
| Chromosome position | 79433111 |
| Reported gene | NRXN3 |
| Mapped gene | NRXN3 |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 9369 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs7141420-T |
| SNPs | rs7141420 |
| Merged | 0 |
| SNP id current | 7141420 |
| Context | intron_variant |
| Intergenic | 0 |
| Allele frequency | 0.527 |
| P value | 0.00000000000001 |
| Pvalue mlog | 14 |
| P value text | (EA) |
| Or beta | 0.024 |
| %95 Ci | [0.017-0.03] kg/m2 increase |
| Platform | Affymetrix, Illumina [2550021] |
| CNV | N |
| Mapped trait | body mass index |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004340 |
| Study accession | GCST002783 |
| PubMed ID | 25673413 |
| Journal | Nature |
| Link | www.ncbi.nlm.nih.gov/pubmed/25673413 |
| Study | Genetic studies of body mass index yield new insights for obesity biology. |
| Disease/Trait | Body mass index |
| Initial sample | up to 104,666 European ancestry male individuals, up to 132,115 European ancestry female individuals, 370 African American male individuals, 517 African American female individuals, 512 Hispanic male individuals, 764 Hispanic female individuals |
| Replication sample | up to 48,274 European ancestry male individuals, up to 39,864 European ancestry female individuals, 2,441 African American or Afro-Caribbean male individuals, 6,314 African American or Afro-Caribbean female individuals, 919 Filipino male individuals, 828 |
| Region | 14q31.1 |
| Chromosome id | chr14 |
| Chromosome position | 79433111 |
| Reported gene | NRXN3 |
| Mapped gene | NRXN3 |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 9369 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs7141420-T |
| SNPs | rs7141420 |
| Merged | 0 |
| SNP id current | 7141420 |
| Context | intron_variant |
| Intergenic | 0 |
| Allele frequency | 0.529 |
| P value | 0.000000000000009 |
| Pvalue mlog | 14.0457574905606 |
| P value text | |
| Or beta | 0.023 |
| %95 Ci | [0.017-0.028] kg/m2 increase |
| Platform | Affymetrix, Illumina [2550021] |
| CNV | N |
| Mapped trait | body mass index |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004340 |
| Study accession | GCST002783 |
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and Xi'an University of Technology ©2014-2017 All Rights Reserved.
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