SNP Detail For rs7134375
1.Mapping Information
Human SNP ID rs7134375
Human chromosome chr12
Human SNP position 20320824
Pig chromosome chr5
Pig SNP position 56035642
2.Annotation Information
PubMed ID20686565
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/20686565
StudyBiological, clinical and population relevance of 95 loci for blood lipids.
Disease/TraitHDL cholesterol
Initial sample99,900 European ancestry individuals
Replication sampleNA
Region12p12.2
Chromosome idchr12
Chromosome position20320824
Reported genePDE3A
Mapped geneLOC105369688
Upstream gene id
Downstream gene id
SNP gene ids105369688
Upstream gene distance
Downstream gene distance
SNP risk allelers7134375-A
SNPsrs7134375
Merged0
SNP id current7134375
Contextintergenic_variant
Intergenic0
Allele frequency0.42
P value0.00000004
Pvalue mlog7.39794000867203
P value text
Or beta0.4
%95 Ci[0.24-0.56] mg/dL increase
PlatformAffymetrix, Illumina, Perlegen [~ 2600000] (imputed)
CNVN
Mapped traithigh density lipoprotein cholesterol measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004612
Study accessionGCST000755
PubMed ID24097068
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24097068
StudyDiscovery and refinement of loci associated with lipid levels.
Disease/TraitHDL cholesterol
Initial sample94,595 European ancestry individuals
Replication sample93,982 European ancestry individuals
Region12p12.2
Chromosome idchr12
Chromosome position20320824
Reported genePDE3A
Mapped geneLOC105369688
Upstream gene id
Downstream gene id
SNP gene ids105369688
Upstream gene distance
Downstream gene distance
SNP risk allelers7134375-A
SNPsrs7134375
Merged0
SNP id current7134375
Contextintergenic_variant
Intergenic0
Allele frequency0.43
P value0.00000001
Pvalue mlog8
P value text
Or beta0.021
%95 Ci[NR] unit increase
PlatformNR [NR] (imputed)
CNVN
Mapped traithigh density lipoprotein cholesterol measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004612
Study accessionGCST002223