SNP Detail For rs7108738
1.Mapping Information
Human SNP ID rs7108738
Human chromosome chr11
Human SNP position 15688538
Pig chromosome chr2
Pig SNP position 46550837
2.Annotation Information
PubMed ID22504420
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22504420
StudyGenome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Disease/TraitBone mineral density
Initial sampleUp to 32,961 European and East Asian ancestry individuals
Replication sampleUp to 50,933 European and East Asian ancestry individuals
Region11p15.2
Chromosome idchr11
Chromosome position15688538
Reported geneSOX6
Mapped geneLOC102724957
Upstream gene id
Downstream gene id
SNP gene ids102724957
Upstream gene distance
Downstream gene distance
SNP risk allelers7108738-T
SNPsrs7108738
Merged0
SNP id current7108738
Contextintron_variant
Intergenic0
Allele frequency0.83
P value1E-32
Pvalue mlog32
P value text(FNBMD)
Or beta0.08
%95 Ci[NR] unit decrease
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitbone density
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003923
Study accessionGCST001482
PubMed ID24249740
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/24249740
StudyMultistage genome-wide association meta-analyses identified two new loci for bone mineral density.
Disease/TraitBone mineral density
Initial sample5,833 European ancestry females, 2,639 European ancestry males, 784 Han Chinese ancestry females, 763 Han Chinese ancestry males, 712 African American females, 409 Hispanic females
Replication sample7,010 European ancestry females, 3,772 European ancestry males, 2,980 East Asian ancestry females, 2,159 East Asian ancestry males
Region11p15.2
Chromosome idchr11
Chromosome position15688538
Reported geneSOX6
Mapped geneLOC102724957
Upstream gene id
Downstream gene id
SNP gene ids102724957
Upstream gene distance
Downstream gene distance
SNP risk allelers7108738-?
SNPsrs7108738
Merged0
SNP id current7108738
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.000000000000001
Pvalue mlog15
P value text(FNK)
Or beta
%95 Ci
PlatformAffymetrix, Illumina [5842825] (imputed)
CNVN
Mapped traitbone density
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0003923
Study accessionGCST002276