Human SNP ID | rs6897932 |
---|---|
Human chromosome | chr5 |
Human SNP position | 35874473 |
Pig chromosome | chr16 |
Pig SNP position | 22310163 |
PubMed ID | 17660530 |
---|---|
Journal | N Engl J Med |
Link | www.ncbi.nlm.nih.gov/pubmed/17660530 |
Study | Risk alleles for multiple sclerosis identified by a genomewide study. |
Disease/Trait | Multiple sclerosis |
Initial sample | 931 European ancestry trios, 2,431 European ancestry controls |
Replication sample | 609 European ancestry trios, 2,322 European ancestry cases, 2,987 European ancestry controls |
Region | 5p13.2 |
Chromosome id | chr5 |
Chromosome position | 35874473 |
Reported gene | IL7RA |
Mapped gene | IL7R |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 3575 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6897932-C |
SNPs | rs6897932 |
Merged | 0 |
SNP id current | 6897932 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | 0.75 |
P value | 0.0000003 |
Pvalue mlog | 6.52287874528033 |
P value text | |
Or beta | 1.18 |
%95 Ci | [1.11-1.26] |
Platform | Affymetrix [334923] |
CNV | N |
Mapped trait | multiple sclerosis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0003885 |
Study accession | GCST000062 |
PubMed ID | 17554260 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/17554260 |
Study | Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. |
Disease/Trait | Type 1 diabetes |
Initial sample | 2,000 European ancestry cases, 3,000 European ancestry controls |
Replication sample | 2,997 European ancestry trios, 4,000 European ancestry cases, 5,000 European ancestry controls |
Region | 5p13.2 |
Chromosome id | chr5 |
Chromosome position | 35874473 |
Reported gene | IL7R |
Mapped gene | IL7R |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 3575 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6897932-G |
SNPs | rs6897932 |
Merged | 0 |
SNP id current | 6897932 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | 0.71 |
P value | 0.000008 |
Pvalue mlog | 5.09691001300805 |
P value text | |
Or beta | 1.12 |
%95 Ci | [1.06-1.19] |
Platform | Affymetrix [NR] |
CNV | N |
Mapped trait | type I diabetes mellitus |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0001359 |
Study accession | GCST000038 |
PubMed ID | 19525953 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/19525953 |
Study | Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. |
Disease/Trait | Multiple sclerosis |
Initial sample | 2,624 European ancestry cases, 7,220 European ancestry controls |
Replication sample | 2,215 European ancestry cases, 2,116 European ancestry controls |
Region | 5p13.2 |
Chromosome id | chr5 |
Chromosome position | 35874473 |
Reported gene | IL7R |
Mapped gene | IL7R |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 3575 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6897932-C |
SNPs | rs6897932 |
Merged | 0 |
SNP id current | 6897932 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | 0.75 |
P value | 0.000002 |
Pvalue mlog | 5.69897000433601 |
P value text | |
Or beta | 1.12 |
%95 Ci | [1.02-1.23] |
Platform | Affymetrix, Illumina [~ 2560000] (imputed) |
CNV | N |
Mapped trait | multiple sclerosis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0003885 |
Study accession | GCST000424 |
PubMed ID | 21833088 |
Journal | Nature |
Link | www.ncbi.nlm.nih.gov/pubmed/21833088 |
Study | Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. |
Disease/Trait | Multiple sclerosis |
Initial sample | 9,772 European ancestry cases, 16,849 European ancestry controls |
Replication sample | 4,218 European ancestry cases, 7,296 European ancestry controls |
Region | 5p13.2 |
Chromosome id | chr5 |
Chromosome position | 35874473 |
Reported gene | IL7R |
Mapped gene | IL7R |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 3575 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6897932-G |
SNPs | rs6897932 |
Merged | 0 |
SNP id current | 6897932 |
Context | missense_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.00000002 |
Pvalue mlog | 7.69897000433601 |
P value text | |
Or beta | 1.11 |
%95 Ci | [1.09-1.13] |
Platform | Illumina [465434] |
CNV | N |
Mapped trait | multiple sclerosis |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0003885 |
Study accession | GCST001198 |