SNP Detail For rs6853847
1.Mapping Information
Human SNP ID rs6853847
Human chromosome chr4
Human SNP position 91996064
Pig chromosome chr8
Pig SNP position 136543608
2.Annotation Information
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region4q22.1
Chromosome idchr4
Chromosome position91996064
Reported geneNR
Mapped geneCCSER1 - PMPCAP1
Upstream gene id401145
Downstream gene id133083
SNP gene ids
Upstream gene distance393845
Downstream gene distance185892
SNP risk allelers6853847-C
SNPsrs6853847
Merged0
SNP id current6853847
Contextintergenic_variant
Intergenic1
Allele frequency0.0304513777282851
P value0.000002
Pvalue mlog5.69897000433601
P value text(IGP24)
Or beta0.4788
%95 Ci[0.28-0.67] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region4q22.1
Chromosome idchr4
Chromosome position91996064
Reported geneNR
Mapped geneCCSER1 - PMPCAP1
Upstream gene id401145
Downstream gene id133083
SNP gene ids
Upstream gene distance393845
Downstream gene distance185892
SNP risk allelers6853847-C
SNPsrs6853847
Merged0
SNP id current6853847
Contextintergenic_variant
Intergenic1
Allele frequency0.0304378588601959
P value0.000005
Pvalue mlog5.30102999566398
P value text(IGP26)
Or beta0.4557
%95 Ci[0.26-0.65] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848