SNP Detail For rs6843082
1.Mapping Information
Human SNP ID rs6843082
Human chromosome chr4
Human SNP position 110796911
Pig chromosome chr8
Pig SNP position 119590536
2.Annotation Information
PubMed ID20173747
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20173747
StudyCommon variants in KCNN3 are associated with lone atrial fibrillation.
Disease/TraitAtrial fibrillation
Initial sample1,335 European ancestry cases, 12,844 European ancestry controls
Replication sample1,164 European ancestry cases, 3,607 European ancestry controls
Region4q25
Chromosome idchr4
Chromosome position110796911
Reported genePITX2
Mapped genePITX2 - MIR297
Upstream gene id5308
Downstream gene id100126354
SNP gene ids
Upstream gene distance154788
Downstream gene distance63671
SNP risk allelers6843082-G
SNPsrs6843082
Merged0
SNP id current6843082
Contextnon_coding_transcript_exon_variant
Intergenic1
Allele frequency0.26
P value3E-28
Pvalue mlog27.5228787452803
P value text
Or beta2.03
%95 Ci[1.79-2.30]
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traitatrial fibrillation
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000275
Study accessionGCST000602
PubMed ID23041239
JournalLancet Neurol
Linkwww.ncbi.nlm.nih.gov/pubmed/23041239
StudyGenetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
Disease/TraitStroke (ischemic)
Initial sample12,389 European ancestry cases, 62,004 European ancestry controls
Replication sample1,322 Pakistani ancestry cases, 1,143 Pakistani ancestry controls, 12,025 European ancestry cases, 27,940 European ancestry controls
Region4q25
Chromosome idchr4
Chromosome position110796911
Reported genePITX2
Mapped genePITX2 - MIR297
Upstream gene id5308
Downstream gene id100126354
SNP gene ids
Upstream gene distance154788
Downstream gene distance63671
SNP risk allelers6843082-G
SNPsrs6843082
Merged0
SNP id current6843082
Contextnon_coding_transcript_exon_variant
Intergenic1
Allele frequency0.21
P value0.0000002
Pvalue mlog6.69897000433601
P value text(IS)
Or beta1.11
%95 Ci[1.06-1.15]
PlatformAffymetrix, Illumina [NR] (imputed)
CNVN
Mapped traitstroke
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000712
Study accessionGCST001706
PubMed ID23041239
JournalLancet Neurol
Linkwww.ncbi.nlm.nih.gov/pubmed/23041239
StudyGenetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
Disease/TraitStroke (ischemic)
Initial sample12,389 European ancestry cases, 62,004 European ancestry controls
Replication sample1,322 Pakistani ancestry cases, 1,143 Pakistani ancestry controls, 12,025 European ancestry cases, 27,940 European ancestry controls
Region4q25
Chromosome idchr4
Chromosome position110796911
Reported genePITX2
Mapped genePITX2 - MIR297
Upstream gene id5308
Downstream gene id100126354
SNP gene ids
Upstream gene distance154788
Downstream gene distance63671
SNP risk allelers6843082-G
SNPsrs6843082
Merged0
SNP id current6843082
Contextnon_coding_transcript_exon_variant
Intergenic1
Allele frequency0.21
P value0.0000000000000003
Pvalue mlog15.5228787452803
P value text(CS)
Or beta1.36
%95 Ci[1.27-1.47]
PlatformAffymetrix, Illumina [NR] (imputed)
CNVN
Mapped traitstroke
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000712
Study accessionGCST001706