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SNP Detail For rs676210
1.Mapping Information
| Human SNP ID | rs676210 |
|---|---|
| Human chromosome | chr2 |
| Human SNP position | 21008652 |
| Pig chromosome | chr3 |
| Pig SNP position | 125342031 |
2.Annotation Information
| PubMed ID | 19936222 |
|---|---|
| Journal | PLoS Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/19936222 |
| Study | Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. |
| Disease/Trait | Lipid metabolism phenotypes |
| Initial sample | Up to 17,296 European ancestry female individuals |
| Replication sample | Up to 2,700 individuals, Up to 2,000 European ancestry cardiovascular heart disease cases and controls |
| Region | 2p24.1 |
| Chromosome id | chr2 |
| Chromosome position | 21008652 |
| Reported gene | APOB |
| Mapped gene | APOB |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 338 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs676210-? |
| SNPs | rs676210 |
| Merged | 0 |
| SNP id current | 676210 |
| Context | missense_variant |
| Intergenic | 0 |
| Allele frequency | NR |
| P value | 0.000000002 |
| Pvalue mlog | 8.69897000433601 |
| P value text | (TG.assay, fasting) |
| Or beta | 0.047 |
| %95 Ci | [NR] unit decrease |
| Platform | Illumina [335603] |
| CNV | N |
| Mapped trait | lipid measurement |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004529 |
| Study accession | GCST000533 |
| PubMed ID | 19936222 |
| Journal | PLoS Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/19936222 |
| Study | Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. |
| Disease/Trait | Lipid metabolism phenotypes |
| Initial sample | Up to 17,296 European ancestry female individuals |
| Replication sample | Up to 2,700 individuals, Up to 2,000 European ancestry cardiovascular heart disease cases and controls |
| Region | 2p24.1 |
| Chromosome id | chr2 |
| Chromosome position | 21008652 |
| Reported gene | APOB |
| Mapped gene | APOB |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 338 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs676210-? |
| SNPs | rs676210 |
| Merged | 0 |
| SNP id current | 676210 |
| Context | missense_variant |
| Intergenic | 0 |
| Allele frequency | NR |
| P value | 4E-64 |
| Pvalue mlog | 63.397940008672 |
| P value text | (VLDL.small, whole) |
| Or beta | 4.219 |
| %95 Ci | [NR] unit decrease |
| Platform | Illumina [335603] |
| CNV | N |
| Mapped trait | lipid measurement |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004529 |
| Study accession | GCST000533 |
| PubMed ID | 19936222 |
| Journal | PLoS Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/19936222 |
| Study | Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. |
| Disease/Trait | Lipid metabolism phenotypes |
| Initial sample | Up to 17,296 European ancestry female individuals |
| Replication sample | Up to 2,700 individuals, Up to 2,000 European ancestry cardiovascular heart disease cases and controls |
| Region | 2p24.1 |
| Chromosome id | chr2 |
| Chromosome position | 21008652 |
| Reported gene | APOB |
| Mapped gene | APOB |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 338 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs676210-? |
| SNPs | rs676210 |
| Merged | 0 |
| SNP id current | 676210 |
| Context | missense_variant |
| Intergenic | 0 |
| Allele frequency | NR |
| P value | 9E-56 |
| Pvalue mlog | 55.0457574905606 |
| P value text | (VLDL.total, whole) |
| Or beta | 6.384 |
| %95 Ci | [NR] unit decrease |
| Platform | Illumina [335603] |
| CNV | N |
| Mapped trait | lipid measurement |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004529 |
| Study accession | GCST000533 |
| PubMed ID | 23247145 |
| Journal | Circ Cardiovasc Genet |
| Link | www.ncbi.nlm.nih.gov/pubmed/23247145 |
| Study | Genome-wide association study pinpoints a new functional apolipoprotein B variant influencing oxidized low-density lipoprotein levels but not cardiovascular events: AtheroRemo Consortium. |
| Disease/Trait | LDL (oxidized) |
| Initial sample | 2,080 European ancestry individuals |
| Replication sample | 4,238 European ancestry individuals |
| Region | 2p24.1 |
| Chromosome id | chr2 |
| Chromosome position | 21008652 |
| Reported gene | apoB |
| Mapped gene | APOB |
| Upstream gene id | |
| Downstream gene id | |
| SNP gene ids | 338 |
| Upstream gene distance | |
| Downstream gene distance | |
| SNP risk allele | rs676210-G |
| SNPs | rs676210 |
| Merged | 0 |
| SNP id current | 676210 |
| Context | missense_variant |
| Intergenic | 0 |
| Allele frequency | 0.77 |
| P value | 3E-47 |
| Pvalue mlog | 46.5228787452803 |
| P value text | |
| Or beta | 10.5 |
| %95 Ci | U/L increase |
| Platform | Illumina [2543887] (imputed) |
| CNV | N |
| Mapped trait | low density lipoprotein cholesterol measurement |
| Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004611 |
| Study accession | GCST001777 |
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