Human SNP ID | rs6733839 |
---|---|
Human chromosome | chr2 |
Human SNP position | 127135234 |
Pig chromosome | chr15 |
Pig SNP position | 28992959 |
PubMed ID | 24162737 |
---|---|
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/24162737 |
Study | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer__s disease. |
Disease/Trait | Alzheimer__s disease (late onset) |
Initial sample | 17,008 European ancestry cases, 37,154 European ancestry controls |
Replication sample | 8,572 European ancestry cases, 11,312 European ancestry controls |
Region | 2q14.3 |
Chromosome id | chr2 |
Chromosome position | 127135234 |
Reported gene | BIN1 |
Mapped gene | LOC105373605 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105373605 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6733839-T |
SNPs | rs6733839 |
Merged | 0 |
SNP id current | 6733839 |
Context | regulatory_region_variant |
Intergenic | 0 |
Allele frequency | 0.409 |
P value | 7E-44 |
Pvalue mlog | 43.1549019599857 |
P value text | |
Or beta | 1.22 |
%95 Ci | [1.18-1.25] |
Platform | Illumina [7055881] (imputed) |
CNV | N |
Mapped trait | Alzheimers disease |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000249 |
Study accession | GCST002245 |
PubMed ID | 25778476 |
Journal | Mol Psychiatry |
Link | www.ncbi.nlm.nih.gov/pubmed/25778476 |
Study | A novel Alzheimer disease locus located near the gene encoding tau protein. |
Disease/Trait | Alzheimer__s disease in APOE e4+ carriers |
Initial sample | 10,352 cases, 9,207 controls |
Replication sample | 1,250 European ancestry cases, 536 European ancestry controls |
Region | 2q14.3 |
Chromosome id | chr2 |
Chromosome position | 127135234 |
Reported gene | BIN1 |
Mapped gene | LOC105373605 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105373605 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6733839-T |
SNPs | rs6733839 |
Merged | 0 |
SNP id current | 6733839 |
Context | regulatory_region_variant |
Intergenic | 0 |
Allele frequency | 0.41 |
P value | 0.000000001 |
Pvalue mlog | 9 |
P value text | |
Or beta | 1.2 |
%95 Ci | [1.13-1.27] |
Platform | NR [NR] |
CNV | N |
Mapped trait | Alzheimers disease |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000249 |
Study accession | GCST002813 |
PubMed ID | 25188341 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/25188341 |
Study | Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer__s Disease and Related Dementias. |
Disease/Trait | Dementia and core Alzheimer__s disease neuropathologic changes |
Initial sample | up to 3,887 cases, up to 1,027 controls |
Replication sample | NA |
Region | 2q14.3 |
Chromosome id | chr2 |
Chromosome position | 127135234 |
Reported gene | BIN1 |
Mapped gene | LOC105373605 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 105373605 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6733839-T |
SNPs | rs6733839 |
Merged | 0 |
SNP id current | 6733839 |
Context | regulatory_region_variant |
Intergenic | 0 |
Allele frequency | 0.43 |
P value | 0.000003 |
Pvalue mlog | 5.52287874528033 |
P value text | (Primary) |
Or beta | 0.3288 |
%95 Ci | [0.19-0.47] unit increase |
Platform | Affymetrix, Illumina [NR] (imputed) |
CNV | N |
Mapped trait | dementia, Alzheimer__s disease neuropathologic change |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0003862, http://www.ebi.ac.uk/efo/EFO_0006801 |
Study accession | GCST002593 |