SNP Detail For rs6687262
1.Mapping Information
Human SNP ID rs6687262
Human chromosome chr1
Human SNP position 79043424
Pig chromosome chr6
Pig SNP position 124494671
2.Annotation Information
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region1p31.1
Chromosome idchr1
Chromosome position79043424
Reported geneNR
Mapped geneADGRL4 - LOC105378810
Upstream gene id64123
Downstream gene id105378810
SNP gene ids
Upstream gene distance36614
Downstream gene distance226980
SNP risk allelers6687262-C
SNPsrs6687262
Merged0
SNP id current6687262
Contextintergenic_variant
Intergenic1
Allele frequency0.552969396260018
P value0.000002
Pvalue mlog5.69897000433601
P value text(IGP31)
Or beta0.1461
%95 Ci[0.085-0.207] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region1p31.1
Chromosome idchr1
Chromosome position79043424
Reported geneNR
Mapped geneADGRL4 - LOC105378810
Upstream gene id64123
Downstream gene id105378810
SNP gene ids
Upstream gene distance36614
Downstream gene distance226980
SNP risk allelers6687262-C
SNPsrs6687262
Merged0
SNP id current6687262
Contextintergenic_variant
Intergenic1
Allele frequency0.553310385988398
P value0.0000004
Pvalue mlog6.39794000867203
P value text(IGP37)
Or beta0.1576
%95 Ci[0.097-0.219] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region1p31.1
Chromosome idchr1
Chromosome position79043424
Reported geneNR
Mapped geneADGRL4 - LOC105378810
Upstream gene id64123
Downstream gene id105378810
SNP gene ids
Upstream gene distance36614
Downstream gene distance226980
SNP risk allelers6687262-C
SNPsrs6687262
Merged0
SNP id current6687262
Contextintergenic_variant
Intergenic1
Allele frequency0.553040158270174
P value0.0000005
Pvalue mlog6.30102999566398
P value text(IGP38)
Or beta0.1567
%95 Ci[0.096-0.218] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848