SNP Detail For rs6570507
1.Mapping Information
Human SNP ID rs6570507
Human chromosome chr6
Human SNP position 142358435
Pig chromosome chr1
Pig SNP position 25348996
2.Annotation Information
PubMed ID19343178
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/19343178
StudyMeta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
Disease/TraitHeight
Initial sample12,611 European ancestry individuals
Replication sample7,187 European ancestry individuals
Region6q24.2
Chromosome idchr6
Chromosome position142358435
Reported geneGPR126
Mapped geneADGRG6
Upstream gene id
Downstream gene id
SNP gene ids57211
Upstream gene distance
Downstream gene distance
SNP risk allelers6570507-?
SNPsrs6570507
Merged0
SNP id current6570507
Contextintron_variant
Intergenic0
Allele frequency0.42
P value0.00000000004
Pvalue mlog10.397940008672
P value text
Or beta0.08
%95 Ci[0.06-0.10] s.d. decrease
PlatformIllumina [229216]
CNVN
Mapped traitbody height
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004339
Study accessionGCST000372
PubMed ID20397748
JournalTwin Res Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/20397748
StudyGenome-wide association study of height and body mass index in Australian twin families.
Disease/TraitHeight
Initial sample11,536 European ancestry individuals
Replication sampleNA
Region6q24.2
Chromosome idchr6
Chromosome position142358435
Reported geneGPR126
Mapped geneADGRG6
Upstream gene id
Downstream gene id
SNP gene ids57211
Upstream gene distance
Downstream gene distance
SNP risk allelers6570507-G
SNPsrs6570507
Merged0
SNP id current6570507
Contextintron_variant
Intergenic0
Allele frequency0.71
P value0.0000002
Pvalue mlog6.69897000433601
P value text
Or beta0.08
%95 Ci[0.04-0.12] SD increase
PlatformIllumina [559712] (imputed)
CNVN
Mapped traitbody height
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004339
Study accessionGCST000644
PubMed ID23666238
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23666238
StudyGenetic variants in GPR126 are associated with adolescent idiopathic scoliosis.
Disease/TraitScoliosis
Initial sample1,033 Japanese ancestry cases, 1,473 Japanese ancestry controls
Replication sample1,529 East Asian ancestry cases, 25,675 East Asian ancestry controls, 447 European ancestry cases, 737 European ancestry controls
Region6q24.2
Chromosome idchr6
Chromosome position142358435
Reported geneGPR126
Mapped geneADGRG6
Upstream gene id
Downstream gene id
SNP gene ids57211
Upstream gene distance
Downstream gene distance
SNP risk allelers6570507-?
SNPsrs6570507
Merged0
SNP id current6570507
Contextintron_variant
Intergenic0
Allele frequency0.43
P value0.000000000004
Pvalue mlog11.397940008672
P value text(East Asian)
Or beta1.26
%95 Ci[1.18-1.35]
PlatformIllumina [465762]
CNVN
Mapped traitscoliosis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004273
Study accessionGCST002020
PubMed ID23666238
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23666238
StudyGenetic variants in GPR126 are associated with adolescent idiopathic scoliosis.
Disease/TraitScoliosis
Initial sample1,033 Japanese ancestry cases, 1,473 Japanese ancestry controls
Replication sample1,529 East Asian ancestry cases, 25,675 East Asian ancestry controls, 447 European ancestry cases, 737 European ancestry controls
Region6q24.2
Chromosome idchr6
Chromosome position142358435
Reported geneGPR126
Mapped geneADGRG6
Upstream gene id
Downstream gene id
SNP gene ids57211
Upstream gene distance
Downstream gene distance
SNP risk allelers6570507-?
SNPsrs6570507
Merged0
SNP id current6570507
Contextintron_variant
Intergenic0
Allele frequency0.43
P value0.00000000000001
Pvalue mlog14
P value text
Or beta1.27
%95 Ci[1.20-1.35]
PlatformIllumina [465762]
CNVN
Mapped traitscoliosis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004273
Study accessionGCST002020
PubMed ID25429064
JournalHum Mol Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25429064
StudyMeta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
Disease/TraitHeight
Initial sample36,227 East Asian ancestry individuals
Replication sample57,699 East Asian ancestry individuals
Region6q24.2
Chromosome idchr6
Chromosome position142358435
Reported geneGPR126
Mapped geneADGRG6
Upstream gene id
Downstream gene id
SNP gene ids57211
Upstream gene distance
Downstream gene distance
SNP risk allelers6570507-A
SNPsrs6570507
Merged0
SNP id current6570507
Contextintron_variant
Intergenic0
Allele frequency0.38
P value0.00000000002
Pvalue mlog10.698970004336
P value text
Or beta0.032
%95 Ci[0.02-0.044] unit decrease
PlatformAffymetrix, Illumina [2704730] (imputed)
CNVN
Mapped traitbody height
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004339
Study accessionGCST002702