SNP Detail For rs6448119
1.Mapping Information
Human SNP ID rs6448119
Human chromosome chr4
Human SNP position 22089761
Pig chromosome chr8
Pig SNP position 16802805
2.Annotation Information
PubMed ID21156761
JournalAnn Rheum Dis
Linkwww.ncbi.nlm.nih.gov/pubmed/21156761
StudyA genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
Disease/TraitRheumatoid arthritis
Initial sample1,147 European ancestry ACPA positive RA cases, 774 European ancestry ACPA negative RA cases, 1,079 European ancestry controls
Replication sample887 European ancestry ACPA positive RA cases, 1,218 European ancestry controls
Region4p15.2
Chromosome idchr4
Chromosome position22089761
Reported geneKCNIP4, GPR125
Mapped geneKCNIP4 - LOC100505912
Upstream gene id80333
Downstream gene id100505912
SNP gene ids
Upstream gene distance140960
Downstream gene distance237593
SNP risk allelers6448119-?
SNPsrs6448119
Merged0
SNP id current6448119
Contextintron_variant
Intergenic1
Allele frequencyNR
P value0.000007
Pvalue mlog5.15490195998574
P value text(ACPA-positive RA vs ACPA-negative RA)
Or beta
%95 Ci
PlatformIllumina [1723056] (imputed)
CNVN
Mapped traitrheumatoid arthritis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000685
Study accessionGCST000917