SNP Detail For rs6432860
1.Mapping Information
Human SNP ID rs6432860
Human chromosome chr2
Human SNP position 166041354
Pig chromosome chr15
Pig SNP position 81066577
2.Annotation Information
PubMed ID25344690
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25344690
StudyCommon variants associated with general and MMR vaccine-related febrile seizures.
Disease/TraitFebrile seizures
Initial sample929 European ancestry MMR vaccine-related febrile seizures cases, 1,070 European ancestry MMR vaccine-unrelated febrile seizures cases, 4,118 European ancestry controls
Replication sampleUp to 408 European ancestry MMR vaccine-related febrile seizures cases, Up to 1,034 European ancestry MMR vaccine-unrelated febrile seizures cases, Up to 1,645 European ancestry controls
Region2q24.3
Chromosome idchr2
Chromosome position166041354
Reported geneSCN1A
Mapped geneSCN1A
Upstream gene id
Downstream gene id
SNP gene ids6323
Upstream gene distance
Downstream gene distance
SNP risk allelers6432860-G
SNPsrs6432860
Merged0
SNP id current6432860
Contextsynonymous_variant
Intergenic0
Allele frequency0.704
P value0.0000000000000002
Pvalue mlog15.698970004336
P value text(Overall)
Or beta1.34
%95 Ci[1.25-1.43]
PlatformIllumina [up to 8129553] (imputed)
CNVN
Mapped traitfebrile seizures
Mapped trait URIhttp://purl.obolibrary.org/obo/HP_0002373
Study accessionGCST002672
PubMed ID25344690
JournalNat Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25344690
StudyCommon variants associated with general and MMR vaccine-related febrile seizures.
Disease/TraitFebrile seizures (MMR vaccine-unrelated)
Initial sample1,070 European ancestry cases, 4,118 European ancestry controls
Replication sampleUp to 1,034 European ancestry cases, Up to 1,645 European ancestry controls
Region2q24.3
Chromosome idchr2
Chromosome position166041354
Reported geneSCN1A
Mapped geneSCN1A
Upstream gene id
Downstream gene id
SNP gene ids6323
Upstream gene distance
Downstream gene distance
SNP risk allelers6432860-G
SNPsrs6432860
Merged0
SNP id current6432860
Contextsynonymous_variant
Intergenic0
Allele frequency0.704
P value0.000000002
Pvalue mlog8.69897000433601
P value text
Or beta1.29
%95 Ci[1.19-1.40]
PlatformIllumina [8129384] (imputed)
CNVN
Mapped traitfebrile seizures
Mapped trait URIhttp://purl.obolibrary.org/obo/HP_0002373
Study accessionGCST002673