SNP Detail For rs643177
1.Mapping Information
Human SNP ID rs643177
Human chromosome chr6
Human SNP position 137874556
Pig chromosome chr1
Pig SNP position 29834072
2.Annotation Information
PubMed ID25574825
JournalAm J Hum Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/25574825
StudyGenome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
Disease/TraitInflammatory skin disease
Initial sample2,079 European ancestry atopic dermatitis cases, 4,212 European ancestry psoriasis cases, 11,899 European ancestry controls
Replication sampleNA
Region6q23.3
Chromosome idchr6
Chromosome position137874556
Reported geneTNFAIP3
Mapped geneTNFAIP3
Upstream gene id
Downstream gene id
SNP gene ids7128
Upstream gene distance
Downstream gene distance
SNP risk allelers643177-?
SNPsrs643177
Merged0
SNP id current643177
Contextintron_variant
Intergenic0
Allele frequencyNR
P value0.0000000000000009
Pvalue mlog15.0457574905606
P value text(Psoriasis)
Or beta1.27
%95 Ci[1.20鈥?.34]
PlatformAffymetrix, Illumina [~ 5200000]
CNVN
Mapped traitpsoriasis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000676
Study accessionGCST002740
PubMed ID25903422
JournalNat Commun
Linkwww.ncbi.nlm.nih.gov/pubmed/25903422
StudyGenome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
Disease/TraitPsoriasis
Initial sample3,496 European ancestry cases, 5,186 European ancestry controls, 1,588 Chinese ancestry cases, 3,546 Chinese ancestry controls
Replication sample5,134 European ancestry cases, 5,633 European ancestry controls, 5,151 Chinese ancestry cases, 5,152 Chinese ancestry controls
Region6q23.3
Chromosome idchr6
Chromosome position137874556
Reported geneTNFAIP3
Mapped geneTNFAIP3
Upstream gene id
Downstream gene id
SNP gene ids7128
Upstream gene distance
Downstream gene distance
SNP risk allelers643177-T
SNPsrs643177
Merged0
SNP id current643177
Contextintron_variant
Intergenic0
Allele frequency0.273
P value0.0000000005
Pvalue mlog9.30102999566398
P value text(EA)
Or beta1.24
%95 Ci[1.16-1.33]
PlatformIllumina [up to 4778154] (imputed)
CNVN
Mapped traitpsoriasis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000676
Study accessionGCST002874
PubMed ID25903422
JournalNat Commun
Linkwww.ncbi.nlm.nih.gov/pubmed/25903422
StudyGenome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
Disease/TraitPsoriasis
Initial sample3,496 European ancestry cases, 5,186 European ancestry controls, 1,588 Chinese ancestry cases, 3,546 Chinese ancestry controls
Replication sample5,134 European ancestry cases, 5,633 European ancestry controls, 5,151 Chinese ancestry cases, 5,152 Chinese ancestry controls
Region6q23.3
Chromosome idchr6
Chromosome position137874556
Reported geneTNFAIP3
Mapped geneTNFAIP3
Upstream gene id
Downstream gene id
SNP gene ids7128
Upstream gene distance
Downstream gene distance
SNP risk allelers643177-T
SNPsrs643177
Merged0
SNP id current643177
Contextintron_variant
Intergenic0
Allele frequency0.273
P value0.000000000009
Pvalue mlog11.0457574905606
P value text
Or beta1.25
%95 Ci[1.17-1.33]
PlatformIllumina [up to 4778154] (imputed)
CNVN
Mapped traitpsoriasis
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000676
Study accessionGCST002874