Human SNP ID | rs6421315 |
---|---|
Human chromosome | chr7 |
Human SNP position | 50315611 |
Pig chromosome | chr9 |
Pig SNP position | 149816893 |
PubMed ID | 23382691 |
---|---|
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 7p12.2 |
Chromosome id | chr7 |
Chromosome position | 50315611 |
Reported gene | IKZF1 |
Mapped gene | IKZF1 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 10320 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6421315-C |
SNPs | rs6421315 |
Merged | 0 |
SNP id current | 6421315 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.368136455031166 |
P value | 0.000007 |
Pvalue mlog | 5.15490195998574 |
P value text | (IGP5) |
Or beta | 0.1445 |
%95 Ci | [0.081-0.208] unit decrease |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 7p12.2 |
Chromosome id | chr7 |
Chromosome position | 50315611 |
Reported gene | IKZF1 |
Mapped gene | IKZF1 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 10320 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6421315-C |
SNPs | rs6421315 |
Merged | 0 |
SNP id current | 6421315 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.368343116206589 |
P value | 0.000000000008 |
Pvalue mlog | 11.096910013008 |
P value text | (IGP62) |
Or beta | 0.2202 |
%95 Ci | [0.16-0.28] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 7p12.2 |
Chromosome id | chr7 |
Chromosome position | 50315611 |
Reported gene | IKZF1 |
Mapped gene | IKZF1 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 10320 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6421315-C |
SNPs | rs6421315 |
Merged | 0 |
SNP id current | 6421315 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.368316756347439 |
P value | 0.0000000000002 |
Pvalue mlog | 12.698970004336 |
P value text | (IGP63) |
Or beta | 0.2363 |
%95 Ci | [0.17-0.3] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 7p12.2 |
Chromosome id | chr7 |
Chromosome position | 50315611 |
Reported gene | IKZF1 |
Mapped gene | IKZF1 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 10320 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6421315-C |
SNPs | rs6421315 |
Merged | 0 |
SNP id current | 6421315 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.368179075211393 |
P value | 0.0000002 |
Pvalue mlog | 6.69897000433601 |
P value text | (IGP64) |
Or beta | 0.1714 |
%95 Ci | [0.11-0.23] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 7p12.2 |
Chromosome id | chr7 |
Chromosome position | 50315611 |
Reported gene | IKZF1 |
Mapped gene | IKZF1 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 10320 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6421315-C |
SNPs | rs6421315 |
Merged | 0 |
SNP id current | 6421315 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.368121119768477 |
P value | 0.0000005 |
Pvalue mlog | 6.30102999566398 |
P value text | (IGP65) |
Or beta | 0.1615 |
%95 Ci | [0.099-0.224] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 7p12.2 |
Chromosome id | chr7 |
Chromosome position | 50315611 |
Reported gene | IKZF1 |
Mapped gene | IKZF1 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 10320 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6421315-C |
SNPs | rs6421315 |
Merged | 0 |
SNP id current | 6421315 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.368179075211393 |
P value | 0.00000000007 |
Pvalue mlog | 10.1549019599857 |
P value text | (IGP67) |
Or beta | 0.2096 |
%95 Ci | [0.15-0.27] unit decrease |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 7p12.2 |
Chromosome id | chr7 |
Chromosome position | 50315611 |
Reported gene | IKZF1 |
Mapped gene | IKZF1 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 10320 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6421315-C |
SNPs | rs6421315 |
Merged | 0 |
SNP id current | 6421315 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.368179075211393 |
P value | 0.00000001 |
Pvalue mlog | 8 |
P value text | (IGP71) |
Or beta | 0.1829 |
%95 Ci | [0.12-0.25] unit decrease |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 7p12.2 |
Chromosome id | chr7 |
Chromosome position | 50315611 |
Reported gene | IKZF1 |
Mapped gene | IKZF1 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 10320 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6421315-C |
SNPs | rs6421315 |
Merged | 0 |
SNP id current | 6421315 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.368120581032947 |
P value | 0.000000008 |
Pvalue mlog | 8.09691001300805 |
P value text | (IGP72) |
Or beta | 0.1863 |
%95 Ci | [0.12-0.25] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |