SNP Detail For rs6258
1.Mapping Information
Human SNP ID rs6258
Human chromosome chr17
Human SNP position 7631360
Pig chromosome chr12
Pig SNP position 55257789
2.Annotation Information
PubMed ID21998597
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/21998597
StudyGenetic determinants of serum testosterone concentrations in men.
Disease/TraitTestosterone levels
Initial sample8,938 European ancestry male individuals
Replication sample5,491 European ancestry male individuals
Region17p13.1
Chromosome idchr17
Chromosome position7631360
Reported geneSHBG
Mapped geneSHBG
Upstream gene id
Downstream gene id
SNP gene ids6462
Upstream gene distance
Downstream gene distance
SNP risk allelers6258-T
SNPsrs6258
Merged0
SNP id current6258
Contextmissense_variant
Intergenic0
Allele frequency0.02
P value2E-22
Pvalue mlog21.698970004336
P value text(Testosterone)
Or beta82.3
%95 Ci[65.64-98.96] ng/dl decrease
PlatformAffymetrix, Illumina [~ 2500000] (imputed)
CNVN
Mapped traittestosterone measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004908
Study accessionGCST001264
PubMed ID22829776
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/22829776
StudyA genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
Disease/TraitSex hormone-binding globulin levels
Initial sample21,791 European ancestry individuals
Replication sample8,175 European ancestry individuals
Region17p13.1
Chromosome idchr17
Chromosome position7631360
Reported geneSHBG
Mapped geneSHBG
Upstream gene id
Downstream gene id
SNP gene ids6462
Upstream gene distance
Downstream gene distance
SNP risk allelers6258-T
SNPsrs6258
Merged0
SNP id current6258
Contextmissense_variant
Intergenic0
Allele frequency0.02
P value3E-46
Pvalue mlog45.5228787452803
P value text(Men + Women, Conditional)
Or beta0.272
%95 Ci[0.24-0.31] unit decrease
PlatformAffymetrix, Illumina [2543887] (imputed)
CNVN
Mapped traitsex hormone globulin binding measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004696
Study accessionGCST001612