Human SNP ID | rs6132333 |
---|---|
Human chromosome | chr20 |
Human SNP position | 20653462 |
Pig chromosome | chr17 |
Pig SNP position | 32558785 |
PubMed ID | 23382691 |
---|---|
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 20p11.23 |
Chromosome id | chr20 |
Chromosome position | 20653462 |
Reported gene | NR |
Mapped gene | RALGAPA2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57186 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6132333-C |
SNPs | rs6132333 |
Merged | 0 |
SNP id current | 6132333 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.0251507142920947 |
P value | 0.000001 |
Pvalue mlog | 6 |
P value text | (IGP23) |
Or beta | 0.5267 |
%95 Ci | [0.31-0.74] unit decrease |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 20p11.23 |
Chromosome id | chr20 |
Chromosome position | 20653462 |
Reported gene | NR |
Mapped gene | RALGAPA2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57186 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6132333-C |
SNPs | rs6132333 |
Merged | 0 |
SNP id current | 6132333 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.0250948889928699 |
P value | 0.000001 |
Pvalue mlog | 6 |
P value text | (IGP25) |
Or beta | 0.5296 |
%95 Ci | [0.31-0.75] unit decrease |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 20p11.23 |
Chromosome id | chr20 |
Chromosome position | 20653462 |
Reported gene | NR |
Mapped gene | RALGAPA2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57186 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6132333-C |
SNPs | rs6132333 |
Merged | 0 |
SNP id current | 6132333 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.0250725390917186 |
P value | 0.000005 |
Pvalue mlog | 5.30102999566398 |
P value text | (IGP27) |
Or beta | 0.5005 |
%95 Ci | [0.29-0.72] unit decrease |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 20p11.23 |
Chromosome id | chr20 |
Chromosome position | 20653462 |
Reported gene | NR |
Mapped gene | RALGAPA2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57186 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6132333-C |
SNPs | rs6132333 |
Merged | 0 |
SNP id current | 6132333 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.0250837167483296 |
P value | 0.000003 |
Pvalue mlog | 5.52287874528033 |
P value text | (IGP32) |
Or beta | 0.5085 |
%95 Ci | [0.29-0.72] unit decrease |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 20p11.23 |
Chromosome id | chr20 |
Chromosome position | 20653462 |
Reported gene | NR |
Mapped gene | RALGAPA2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57186 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6132333-C |
SNPs | rs6132333 |
Merged | 0 |
SNP id current | 6132333 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.0251061037895675 |
P value | 0.0000007 |
Pvalue mlog | 6.15490195998574 |
P value text | (IGP33) |
Or beta | 0.5397 |
%95 Ci | [0.33-0.75] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |
PubMed ID | 23382691 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/23382691 |
Study | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |
Disease/Trait | IgG glycosylation |
Initial sample | 2,247 European ancestry individuals |
Replication sample | NA |
Region | 20p11.23 |
Chromosome id | chr20 |
Chromosome position | 20653462 |
Reported gene | NR |
Mapped gene | RALGAPA2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57186 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs6132333-C |
SNPs | rs6132333 |
Merged | 0 |
SNP id current | 6132333 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.0251061037895675 |
P value | 0.000008 |
Pvalue mlog | 5.09691001300805 |
P value text | (IGP34) |
Or beta | 0.4924 |
%95 Ci | [0.28-0.71] unit increase |
Platform | Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | serum IgG glycosylation measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0005193 |
Study accession | GCST001848 |