SNP Detail For rs6132333
1.Mapping Information
Human SNP ID rs6132333
Human chromosome chr20
Human SNP position 20653462
Pig chromosome chr17
Pig SNP position 32558785
2.Annotation Information
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region20p11.23
Chromosome idchr20
Chromosome position20653462
Reported geneNR
Mapped geneRALGAPA2
Upstream gene id
Downstream gene id
SNP gene ids57186
Upstream gene distance
Downstream gene distance
SNP risk allelers6132333-C
SNPsrs6132333
Merged0
SNP id current6132333
Contextintron_variant
Intergenic0
Allele frequency0.0251507142920947
P value0.000001
Pvalue mlog6
P value text(IGP23)
Or beta0.5267
%95 Ci[0.31-0.74] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region20p11.23
Chromosome idchr20
Chromosome position20653462
Reported geneNR
Mapped geneRALGAPA2
Upstream gene id
Downstream gene id
SNP gene ids57186
Upstream gene distance
Downstream gene distance
SNP risk allelers6132333-C
SNPsrs6132333
Merged0
SNP id current6132333
Contextintron_variant
Intergenic0
Allele frequency0.0250948889928699
P value0.000001
Pvalue mlog6
P value text(IGP25)
Or beta0.5296
%95 Ci[0.31-0.75] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region20p11.23
Chromosome idchr20
Chromosome position20653462
Reported geneNR
Mapped geneRALGAPA2
Upstream gene id
Downstream gene id
SNP gene ids57186
Upstream gene distance
Downstream gene distance
SNP risk allelers6132333-C
SNPsrs6132333
Merged0
SNP id current6132333
Contextintron_variant
Intergenic0
Allele frequency0.0250725390917186
P value0.000005
Pvalue mlog5.30102999566398
P value text(IGP27)
Or beta0.5005
%95 Ci[0.29-0.72] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region20p11.23
Chromosome idchr20
Chromosome position20653462
Reported geneNR
Mapped geneRALGAPA2
Upstream gene id
Downstream gene id
SNP gene ids57186
Upstream gene distance
Downstream gene distance
SNP risk allelers6132333-C
SNPsrs6132333
Merged0
SNP id current6132333
Contextintron_variant
Intergenic0
Allele frequency0.0250837167483296
P value0.000003
Pvalue mlog5.52287874528033
P value text(IGP32)
Or beta0.5085
%95 Ci[0.29-0.72] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region20p11.23
Chromosome idchr20
Chromosome position20653462
Reported geneNR
Mapped geneRALGAPA2
Upstream gene id
Downstream gene id
SNP gene ids57186
Upstream gene distance
Downstream gene distance
SNP risk allelers6132333-C
SNPsrs6132333
Merged0
SNP id current6132333
Contextintron_variant
Intergenic0
Allele frequency0.0251061037895675
P value0.0000007
Pvalue mlog6.15490195998574
P value text(IGP33)
Or beta0.5397
%95 Ci[0.33-0.75] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region20p11.23
Chromosome idchr20
Chromosome position20653462
Reported geneNR
Mapped geneRALGAPA2
Upstream gene id
Downstream gene id
SNP gene ids57186
Upstream gene distance
Downstream gene distance
SNP risk allelers6132333-C
SNPsrs6132333
Merged0
SNP id current6132333
Contextintron_variant
Intergenic0
Allele frequency0.0251061037895675
P value0.000008
Pvalue mlog5.09691001300805
P value text(IGP34)
Or beta0.4924
%95 Ci[0.28-0.71] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848