SNP Detail For rs6102185
1.Mapping Information
Human SNP ID rs6102185
Human chromosome chr20
Human SNP position 40849893
Pig chromosome chr17
Pig SNP position 48942367
2.Annotation Information
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region20q12
Chromosome idchr20
Chromosome position40849893
Reported geneNR
Mapped geneLOC101927098 - LOC100128988
Upstream gene id101927098
Downstream gene id100128988
SNP gene ids
Upstream gene distance132577
Downstream gene distance130144
SNP risk allelers6102185-G
SNPsrs6102185
Merged0
SNP id current6102185
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.422812170677362
P value0.000002
Pvalue mlog5.69897000433601
P value text(IGP25)
Or beta0.1489
%95 Ci[0.088-0.21] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region20q12
Chromosome idchr20
Chromosome position40849893
Reported geneNR
Mapped geneLOC101927098 - LOC100128988
Upstream gene id101927098
Downstream gene id100128988
SNP gene ids
Upstream gene distance132577
Downstream gene distance130144
SNP risk allelers6102185-G
SNPsrs6102185
Merged0
SNP id current6102185
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.423097751558326
P value0.000001
Pvalue mlog6
P value text(IGP27)
Or beta0.151
%95 Ci[0.09-0.212] unit increase
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848
PubMed ID23382691
JournalPLoS Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/23382691
StudyLoci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Disease/TraitIgG glycosylation
Initial sample2,247 European ancestry individuals
Replication sampleNA
Region20q12
Chromosome idchr20
Chromosome position40849893
Reported geneNR
Mapped geneLOC101927098 - LOC100128988
Upstream gene id101927098
Downstream gene id100128988
SNP gene ids
Upstream gene distance132577
Downstream gene distance130144
SNP risk allelers6102185-G
SNPsrs6102185
Merged0
SNP id current6102185
Contextdownstream_gene_variant
Intergenic1
Allele frequency0.422547655372269
P value0.000005
Pvalue mlog5.30102999566398
P value text(IGP34)
Or beta0.1429
%95 Ci[0.082-0.204] unit decrease
PlatformIllumina [~ 2500000] (imputed)
CNVN
Mapped traitserum IgG glycosylation measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0005193
Study accessionGCST001848