SNP Detail For rs608114
1.Mapping Information
Human SNP ID rs608114
Human chromosome chr6
Human SNP position 95928822
Pig chromosome chr1
Pig SNP position 71373337
2.Annotation Information
PubMed ID25461247
JournalPharmacogenet Genomics
Linkwww.ncbi.nlm.nih.gov/pubmed/25461247
StudyGenome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.
Disease/TraitResponse to abacavir-containing treatment in HIV-1 infection (virologic failure)
Initial sampleUp 346 European ancestry individuals, Up to 265 Black individuals, Up to 175 Hispanic individuals
Replication sampleNA
Region6q16.1
Chromosome idchr6
Chromosome position95928822
Reported geneNR
Mapped geneMANEA - KRT18P50
Upstream gene id79694
Downstream gene id442236
SNP gene ids
Upstream gene distance319370
Downstream gene distance62276
SNP risk allelers608114-A
SNPsrs608114
Merged0
SNP id current608114
Contextintergenic_variant
Intergenic1
Allele frequencyNR
P value0.0000003
Pvalue mlog6.52287874528033
P value text(phenotype 3)
Or beta4.84
%95 Ci[NR]
PlatformIllumina [> 8000000] (imputed)
CNVN
Mapped traitHIV-1 infection, virologic response measurement, response to abacavir
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000180, http://www.ebi.ac.uk/efo/EFO_0006906, http://www.ebi.ac.uk/efo/EFO_0006905
Study accessionGCST002769
PubMed ID25461247
JournalPharmacogenet Genomics
Linkwww.ncbi.nlm.nih.gov/pubmed/25461247
StudyGenome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols.
Disease/TraitResponse to efavirenz-containing treatment in HIV 1 infection (virologic failure)
Initial sampleUp to 737 European ancestry individuals, Up to 545 Black individuals, Up to 314 Hispanic individuals
Replication sampleNA
Region6q16.1
Chromosome idchr6
Chromosome position95928822
Reported geneNR
Mapped geneMANEA - KRT18P50
Upstream gene id79694
Downstream gene id442236
SNP gene ids
Upstream gene distance319370
Downstream gene distance62276
SNP risk allelers608114-A
SNPsrs608114
Merged0
SNP id current608114
Contextintergenic_variant
Intergenic1
Allele frequencyNR
P value0.0000003
Pvalue mlog6.52287874528033
P value text(phenotype 1)
Or beta4.84
%95 Ci[NR]
PlatformIllumina [> 8000000] (imputed)
CNVN
Mapped traitHIV-1 infection, response to efavirenz, virologic response measurement
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0000180, http://www.ebi.ac.uk/efo/EFO_0006904, http://www.ebi.ac.uk/efo/EFO_0006906
Study accessionGCST002771