SNP Detail For rs56117933
1.Mapping Information
Human SNP ID rs56117933
Human chromosome chr15
Human SNP position 78540007
Pig chromosome chr7
Pig SNP position 52939379
2.Annotation Information
PubMed ID26634245
JournalBMC Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26634245
StudyA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Disease/TraitPost bronchodilator FEV1
Initial sample10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals
Replication sampleNA
Region15q25.1
Chromosome idchr15
Chromosome position78540007
Reported geneIntergenic
Mapped geneHYKK - PSMA4
Upstream gene id123688
Downstream gene id5685
SNP gene ids
Upstream gene distance2634
Downstream gene distance398
SNP risk allelers56117933-T
SNPsrs56117933
Merged0
SNP id current56117933
Contextupstream_gene_variant
Intergenic1
Allele frequency0.79
P value0.0000000003
Pvalue mlog9.52287874528033
P value text
Or beta0.082
%95 CiNR unit increase
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitforced expiratory volume, response to bronchodilator
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004314, http://purl.obolibrary.org/obo/GO_0097366
Study accessionGCST003262
PubMed ID26634245
JournalBMC Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26634245
StudyA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Disease/TraitPost bronchodilator FEV1/FVC ratio in COPD
Initial sample5,439 European ancestry current and former smoker cases, 821 African American current and former smoker cases
Replication sampleNA
Region15q25.1
Chromosome idchr15
Chromosome position78540007
Reported geneIntergenic
Mapped geneHYKK - PSMA4
Upstream gene id123688
Downstream gene id5685
SNP gene ids
Upstream gene distance2634
Downstream gene distance398
SNP risk allelers56117933-T
SNPsrs56117933
Merged0
SNP id current56117933
Contextupstream_gene_variant
Intergenic1
Allele frequency0.762
P value0.000001
Pvalue mlog6
P value text
Or beta0.015
%95 CiNR unit increase
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitresponse to bronchodilator, chronic obstructive pulmonary disease, FEV/FEC ratio
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0000341, http://www.ebi.ac.uk/efo/EFO_0004713
Study accessionGCST003265
PubMed ID26634245
JournalBMC Genet
Linkwww.ncbi.nlm.nih.gov/pubmed/26634245
StudyA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Disease/TraitPost bronchodilator FEV1/FVC ratio
Initial sample10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals
Replication sampleNA
Region15q25.1
Chromosome idchr15
Chromosome position78540007
Reported geneIntergenic
Mapped geneHYKK - PSMA4
Upstream gene id123688
Downstream gene id5685
SNP gene ids
Upstream gene distance2634
Downstream gene distance398
SNP risk allelers56117933-T
SNPsrs56117933
Merged0
SNP id current56117933
Contextupstream_gene_variant
Intergenic1
Allele frequency0.792
P value0.00000000005
Pvalue mlog10.3010299956639
P value text
Or beta0.018
%95 Ciunit increase
PlatformIllumina [NR] (imputed)
CNVN
Mapped traitresponse to bronchodilator, FEV/FEC ratio
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0097366, http://www.ebi.ac.uk/efo/EFO_0004713
Study accessionGCST003264