Human SNP ID | rs560887 |
---|---|
Human chromosome | chr2 |
Human SNP position | 168906638 |
Pig chromosome | chr15 |
Pig SNP position | 84491385 |
PubMed ID | 18451265 |
---|---|
Journal | Science |
Link | www.ncbi.nlm.nih.gov/pubmed/18451265 |
Study | A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. |
Disease/Trait | Fasting plasma glucose |
Initial sample | 654 European ancestry individuals |
Replication sample | 9,353 European ancestry individuals |
Region | 2q31.1 |
Chromosome id | chr2 |
Chromosome position | 168906638 |
Reported gene | G6PC2 |
Mapped gene | G6PC2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57818 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs560887-A |
SNPs | rs560887 |
Merged | 0 |
SNP id current | 560887 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.3 |
P value | 4E-23 |
Pvalue mlog | 22.397940008672 |
P value text | |
Or beta | 0.06 |
%95 Ci | [0.05-0.08] mmol/l decrease |
Platform | Illumina [392935] |
CNV | N |
Mapped trait | fasting blood glucose measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004465 |
Study accession | GCST000205 |
PubMed ID | 19060910 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/19060910 |
Study | Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. |
Disease/Trait | Metabolic traits |
Initial sample | 4,763 Northern Finnish founder individuals |
Replication sample | NA |
Region | 2q31.1 |
Chromosome id | chr2 |
Chromosome position | 168906638 |
Reported gene | G6PC2, ABCB11 |
Mapped gene | G6PC2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57818 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs560887-A |
SNPs | rs560887 |
Merged | 0 |
SNP id current | 560887 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.31 |
P value | 0.0000000006 |
Pvalue mlog | 9.22184874961635 |
P value text | (GLU) |
Or beta | 0.06 |
%95 Ci | [0.04-0.07] mmol/l decrease |
Platform | Illumina [329091] |
CNV | N |
Mapped trait | glucose measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004468 |
Study accession | GCST000292 |
PubMed ID | 19060907 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/19060907 |
Study | Variants in MTNR1B influence fasting glucose levels. |
Disease/Trait | Fasting plasma glucose |
Initial sample | 35,812 European ancestry individuals |
Replication sample | NA |
Region | 2q31.1 |
Chromosome id | chr2 |
Chromosome position | 168906638 |
Reported gene | G6PC2 |
Mapped gene | G6PC2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57818 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs560887-C |
SNPs | rs560887 |
Merged | 0 |
SNP id current | 560887 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.7 |
P value | 1E-57 |
Pvalue mlog | 57 |
P value text | |
Or beta | 0.06 |
%95 Ci | [0.05-0.07] mmol/l increase |
Platform | Affymetrix, Illumina, Perlegen [up to 2557249] (imputed) |
CNV | N |
Mapped trait | fasting blood glucose measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004465 |
Study accession | GCST000276 |
PubMed ID | 22286219 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/22286219 |
Study | Genome-wide association study identifies multiple loci influencing human serum metabolite levels. |
Disease/Trait | Metabolite levels |
Initial sample | 8,330 European ancestry individuals |
Replication sample | NA |
Region | 2q31.1 |
Chromosome id | chr2 |
Chromosome position | 168906638 |
Reported gene | G6PC2 |
Mapped gene | G6PC2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57818 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs560887-? |
SNPs | rs560887 |
Merged | 0 |
SNP id current | 560887 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 0.00000000000000002 |
Pvalue mlog | 16.698970004336 |
P value text | (Glc) |
Or beta | 0.15 |
%95 Ci | [0.11-0.19] unit increase |
Platform | Illumina [~ 7700000] (imputed) |
CNV | N |
Mapped trait | metabolite measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004725 |
Study accession | GCST001391 |
PubMed ID | 22399527 |
Journal | Circ Cardiovasc Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/22399527 |
Study | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. |
Disease/Trait | Metabolic syndrome |
Initial sample | 2,637 European ancestry cases, 7,927 European ancestry controls |
Replication sample | NA |
Region | 2q31.1 |
Chromosome id | chr2 |
Chromosome position | 168906638 |
Reported gene | G6PC2 |
Mapped gene | G6PC2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57818 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs560887-G |
SNPs | rs560887 |
Merged | 0 |
SNP id current | 560887 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.69 |
P value | 5E-26 |
Pvalue mlog | 25.3010299956639 |
P value text | (GLU) |
Or beta | 0.15 |
%95 Ci | [NR] mmol/l increase |
Platform | Illumina [1257079] (imputed) |
CNV | N |
Mapped trait | metabolic syndrome |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0000195 |
Study accession | GCST001436 |
PubMed ID | 22508271 |
Journal | Genet Epidemiol |
Link | www.ncbi.nlm.nih.gov/pubmed/22508271 |
Study | Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA). |
Disease/Trait | Fasting plasma glucose |
Initial sample | 2,349 European ancestry individuals, 664 Chinese ancestry individuals, 1,366 African American individuals, 1,171 Hispanic individuals |
Replication sample | NA |
Region | 2q31.1 |
Chromosome id | chr2 |
Chromosome position | 168906638 |
Reported gene | G6PC2 |
Mapped gene | G6PC2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57818 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs560887-T |
SNPs | rs560887 |
Merged | 0 |
SNP id current | 560887 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.2 |
P value | 0.000002 |
Pvalue mlog | 5.69897000433601 |
P value text | (fasting glucose) |
Or beta | 1.29 |
%95 Ci | [0.84-1.74] mg/dL decrease |
Platform | Affymetrix [NR] (imputed) |
CNV | N |
Mapped trait | fasting blood glucose measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004465 |
Study accession | GCST001486 |
PubMed ID | 20081858 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/20081858 |
Study | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. |
Disease/Trait | Fasting glucose-related traits |
Initial sample | up to 46,186 European ancestry individuals |
Replication sample | up to 76,558 European ancestry individuals |
Region | 2q31.1 |
Chromosome id | chr2 |
Chromosome position | 168906638 |
Reported gene | G6PC2 |
Mapped gene | G6PC2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57818 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs560887-C |
SNPs | rs560887 |
Merged | 0 |
SNP id current | 560887 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.7 |
P value | 9E-218 |
Pvalue mlog | 217.04575749056 |
P value text | (FPG) |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | fasting blood glucose measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004465 |
Study accession | GCST000568 |
PubMed ID | 20081858 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/20081858 |
Study | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. |
Disease/Trait | Fasting glucose-related traits |
Initial sample | up to 46,186 European ancestry individuals |
Replication sample | up to 76,558 European ancestry individuals |
Region | 2q31.1 |
Chromosome id | chr2 |
Chromosome position | 168906638 |
Reported gene | G6PC2 |
Mapped gene | G6PC2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57818 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs560887-C |
SNPs | rs560887 |
Merged | 0 |
SNP id current | 560887 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.7 |
P value | 2E-66 |
Pvalue mlog | 65.698970004336 |
P value text | (HOMA-B) |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Illumina [~ 2500000] (imputed) |
CNV | N |
Mapped trait | HOMA-B |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004469 |
Study accession | GCST000568 |
PubMed ID | 22581228 |
Journal | Nat Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/22581228 |
Study | A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. |
Disease/Trait | Fasting glucose-related traits (interaction with BMI) |
Initial sample | Up to 58,074 European ancestry individuals |
Replication sample | Up tp 38,422 European ancestry individuals |
Region | 2q31.1 |
Chromosome id | chr2 |
Chromosome position | 168906638 |
Reported gene | G6PC2 |
Mapped gene | G6PC2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57818 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs560887-? |
SNPs | rs560887 |
Merged | 0 |
SNP id current | 560887 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | NR |
P value | 2E-113 |
Pvalue mlog | 112.698970004336 |
P value text | |
Or beta | |
%95 Ci | |
Platform | Affymetrix, Illumina [~ 2400000] (imputed) |
CNV | N |
Mapped trait | body mass index, fasting blood glucose measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004340, http://www.ebi.ac.uk/efo/EFO_0004465 |
Study accession | GCST001527 |
PubMed ID | 22916037 |
Journal | PLoS Genet |
Link | www.ncbi.nlm.nih.gov/pubmed/22916037 |
Study | Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. |
Disease/Trait | Metabolite levels |
Initial sample | 6,608 European ancestry individuals |
Replication sample | NA |
Region | 2q31.1 |
Chromosome id | chr2 |
Chromosome position | 168906638 |
Reported gene | G6PC2 |
Mapped gene | G6PC2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57818 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs560887-? |
SNPs | rs560887 |
Merged | 0 |
SNP id current | 560887 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.31 |
P value | 0.000000000000004 |
Pvalue mlog | 14.397940008672 |
P value text | |
Or beta | |
%95 Ci | |
Platform | Illumina [~ 2000000] (imputed) |
CNV | N |
Mapped trait | coronary artery calcification |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004723 |
Study accession | GCST001639 |
PubMed ID | 23903356 |
Journal | Diabetes |
Link | www.ncbi.nlm.nih.gov/pubmed/23903356 |
Study | Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. |
Disease/Trait | Glycemic traits (pregnancy) |
Initial sample | 1,367 European ancestry individuals, 817 Hispanic individuals, 1,075 Afro-Caribbean individuals, 1,178 Thai ancestry individuals |
Replication sample | 2,798 European ancestry individuals, 228 French Canadian founder population individuals |
Region | 2q31.1 |
Chromosome id | chr2 |
Chromosome position | 168906638 |
Reported gene | G6PC2 |
Mapped gene | G6PC2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57818 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs560887-T |
SNPs | rs560887 |
Merged | 0 |
SNP id current | 560887 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.291 |
P value | 0.0000000000000002 |
Pvalue mlog | 15.698970004336 |
P value text | (FPG) |
Or beta | 0.0061 |
%95 Ci | [NR] unit decrease |
Platform | Illumina [up to 945994] (imputed) |
CNV | N |
Mapped trait | fasting blood glucose measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004465 |
Study accession | GCST002110 |
PubMed ID | 24405752 |
Journal | Metabolism |
Link | www.ncbi.nlm.nih.gov/pubmed/24405752 |
Study | Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). |
Disease/Trait | Glycated hemoglobin levels |
Initial sample | 4,088 European ancestry non-diabetic elderly individuals |
Replication sample | up to 47,822 European ancestry non-diabetic elderly individuals |
Region | 2q31.1 |
Chromosome id | chr2 |
Chromosome position | 168906638 |
Reported gene | G6PC2 |
Mapped gene | G6PC2 |
Upstream gene id | |
Downstream gene id | |
SNP gene ids | 57818 |
Upstream gene distance | |
Downstream gene distance | |
SNP risk allele | rs560887-T |
SNPs | rs560887 |
Merged | 0 |
SNP id current | 560887 |
Context | intron_variant |
Intergenic | 0 |
Allele frequency | 0.33 |
P value | 0.00000000000000001 |
Pvalue mlog | 17 |
P value text | |
Or beta | 0.032 |
%95 Ci | [0.024-0.040] unit decrease |
Platform | Illumina [9250000] (imputed) |
CNV | N |
Mapped trait | A1C measurement |
Mapped trait URI | http://www.ebi.ac.uk/efo/EFO_0004541 |
Study accession | GCST002303 |