SNP Detail For rs4722585
1.Mapping Information
Human SNP ID rs4722585
Human chromosome chr7
Human SNP position 26143746
Pig chromosome chr18
Pig SNP position 51030650
2.Annotation Information
PubMed ID24554482
JournalJ Neurovirol
Linkwww.ncbi.nlm.nih.gov/pubmed/24554482
StudyGenome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
Disease/TraitResponse to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy)
Initial sample40 European ancestry cases, 37 African American cases, 13 Hispanic cases, 85 European ancestry controls, 49 African American controls, 30 Hispanic controls
Replication sampleNA
Region7p15.2
Chromosome idchr7
Chromosome position26143746
Reported geneNFE2L3
Mapped geneLOC105375199 - NFE2L3
Upstream gene id105375199
Downstream gene id9603
SNP gene ids
Upstream gene distance12816
Downstream gene distance8481
SNP risk allelers4722585-?
SNPsrs4722585
Merged0
SNP id current4722585
Contextregulatory_region_variant
Intergenic1
Allele frequency
P value0.000005
Pvalue mlog5.30102999566398
P value text(AA)
Or beta0.2
%95 Ci[NR]
PlatformIllumina [936149]
CNVN
Mapped traitresponse to reverse transcriptase inhibitor, HIV-1 infection, peripheral neuropathy
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0061479, http://www.ebi.ac.uk/efo/EFO_0000180, http://www.ebi.ac.uk/efo/EFO_0003100
Study accessionGCST002366
PubMed ID24554482
JournalJ Neurovirol
Linkwww.ncbi.nlm.nih.gov/pubmed/24554482
StudyGenome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
Disease/TraitResponse to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy)
Initial sample19 European ancestry cases, 30 African American cases, 9 Hispanic cases, 85 European ancestry controls, 49 African American controls, 30 Hispanic controls
Replication sampleNA
Region7p15.2
Chromosome idchr7
Chromosome position26143746
Reported geneNFE2L3
Mapped geneLOC105375199 - NFE2L3
Upstream gene id105375199
Downstream gene id9603
SNP gene ids
Upstream gene distance12816
Downstream gene distance8481
SNP risk allelers4722585-?
SNPsrs4722585
Merged0
SNP id current4722585
Contextregulatory_region_variant
Intergenic1
Allele frequency
P value0.000005
Pvalue mlog5.30102999566398
P value text(AA)
Or beta0.2
%95 Ci[NR]
PlatformIllumina [936149]
CNVN
Mapped traitresponse to reverse transcriptase inhibitor, HIV-1 infection, peripheral neuropathy
Mapped trait URIhttp://purl.obolibrary.org/obo/GO_0061479, http://www.ebi.ac.uk/efo/EFO_0000180, http://www.ebi.ac.uk/efo/EFO_0003100
Study accessionGCST002365