SNP Detail For rs4714699
1.Mapping Information
Human SNP ID rs4714699
Human chromosome chr6
Human SNP position 43834826
Pig chromosome chr7
Pig SNP position 44532881
2.Annotation Information
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region6p21.1
Chromosome idchr6
Chromosome position43834826
Reported geneVEGFA
Mapped geneLOC105375070 - LOC105375069
Upstream gene id105375070
Downstream gene id105375069
SNP gene ids
Upstream gene distance13124
Downstream gene distance2106
SNP risk allelers4714699-C
SNPsrs4714699
Merged0
SNP id current4714699
Contextintron_variant
Intergenic1
Allele frequency0.3799
P value0.000001
Pvalue mlog6
P value text(EA, women)
Or beta0.0241
%95 Ci[0.014-0.034] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782
PubMed ID25673412
JournalNature
Linkwww.ncbi.nlm.nih.gov/pubmed/25673412
StudyNew genetic loci link adipose and insulin biology to body fat distribution.
Disease/TraitWaist-to-hip ratio adjusted for body mass index
Initial sampleup to 56,910 European ancestry men, up to 86,570 European ancestry women
Replication sampleup to 36,570 European ancestry men, 30,172 European ancestry women, 915 Filipino ancestry men, 735 Filipino ancestry women, 2,351 African-American/Afro-Caribbean ancestry men, 6,258 African-American/Afro-Caribbean ancestry women, 2,285 South Asian ancestr
Region6p21.1
Chromosome idchr6
Chromosome position43834826
Reported geneVEGFA
Mapped geneLOC105375070 - LOC105375069
Upstream gene id105375070
Downstream gene id105375069
SNP gene ids
Upstream gene distance13124
Downstream gene distance2106
SNP risk allelers4714699-C
SNPsrs4714699
Merged0
SNP id current4714699
Contextintron_variant
Intergenic1
Allele frequency0.3747
P value0.000002
Pvalue mlog5.69897000433601
P value text(women)
Or beta0.0233
%95 Ci[0.014-0.033] unit increase
PlatformAffymetrix, Illumina, Perlegen [up to 2542447] (imputed)
CNVN
Mapped traitwaist-hip ratio, body mass index
Mapped trait URIhttp://www.ebi.ac.uk/efo/EFO_0004343, http://www.ebi.ac.uk/efo/EFO_0004340
Study accessionGCST002782